QUANTITATIVE ASSESSMENT OF SALIVARY GLAND FUNCTION BY RADIOISOTOPIC SCANNING IN A RANDOMIZED TRIAL OF PILOCARPINE FOR PREVENTION OF RADIATION INDUCED XEROSTOMIA

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FARD-ESRAHANI A.; MODARES MOSALA S.M.M.; EFTEKHARI MEHRDAD; SAGHARI M.; HADAD P.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2001 | Volume:- | Issue:14-15 Page(s): 11-20

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Title

QUANTITATIVE ASSESSMENT OF SALIVARY GLAND FUNCTION BY RADIOISOTOPIC SCANNING IN A RANDOMIZED TRIAL OF PILOCARPINE FOR PREVENTION OF RADIATION INDUCED XEROSTOMIA

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Abstract

Introduction. Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods. Patients randomized in a placebo-controlled trial of pilocarpine concurrent with irradiation for prevention of radiation-induced xerostomia were evaluated by salivary gland scintigraphy immediately before and 6 months after the end of head and neck radiotherapy. Salivary gland function was measured by ejection fraction (EF) of Technetium-99m pertechnetate. The mean values for pre-and post-radiotherapy scans were calculated and compared. Also post-radiotherapy scan findings in the two groups of pilocarpine and placebo were compared using the Student’s t-test. In addition, comparison was made between the scan results and the subjective findings and objective gradings. Results. Twenty patients underwent the pre-radiotherapy salivary scintigraphy, and also 20 post-radiotherapy scans were performed. Mean parotid EF was 60.85% in the pre-radiotherapy and 9.08% in the post-radiotherapy scans (p<0.01). The means for submandibular glands in the pre-and post-radiotherapy scans were 41% and 11.2% , respectively (p<0.01). Also the mean EF was 14.5% in the pilocarpine group and 3.65 in the placebo group for parotid glands (p=0.07) and 18.3% and 4.1% respectively for submandibular glands (p<0.05). The salivary scans confirmed the subjective and objective xerostomia findings. Conclusion. Salivary gland scintigraphy is a valuable method for evaluation of xerostomia after head and neck radiotherapy, quantitatively demonstrating the protective effect of pilocarpine compared to placebo on salivary glands.

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APA: Copy

FARD-ESRAHANI, A., MODARES MOSALA, S.M.M., EFTEKHARI, MEHRDAD, SAGHARI, M., & HADAD, P.. (2001). QUANTITATIVE ASSESSMENT OF SALIVARY GLAND FUNCTION BY RADIOISOTOPIC SCANNING IN A RANDOMIZED TRIAL OF PILOCARPINE FOR PREVENTION OF RADIATION INDUCED XEROSTOMIA. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(14-15), 11-20. SID. https://sid.ir/paper/542160/en

Vancouver: Copy

FARD-ESRAHANI A., MODARES MOSALA S.M.M., EFTEKHARI MEHRDAD, SAGHARI M., HADAD P.. QUANTITATIVE ASSESSMENT OF SALIVARY GLAND FUNCTION BY RADIOISOTOPIC SCANNING IN A RANDOMIZED TRIAL OF PILOCARPINE FOR PREVENTION OF RADIATION INDUCED XEROSTOMIA. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2001;-(14-15):11-20. Available from: https://sid.ir/paper/542160/en

IEEE: Copy

A. FARD-ESRAHANI, S.M.M. MODARES MOSALA, MEHRDAD EFTEKHARI, M. SAGHARI, and P. HADAD, “QUANTITATIVE ASSESSMENT OF SALIVARY GLAND FUNCTION BY RADIOISOTOPIC SCANNING IN A RANDOMIZED TRIAL OF PILOCARPINE FOR PREVENTION OF RADIATION INDUCED XEROSTOMIA,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 14-15, pp. 11–20, 2001, [Online]. Available: https://sid.ir/paper/542160/en

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