GENETIC MODIFICATION OF HUMAN EMBRYONIC STEM CELLS

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CUI W.

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2008 | Volume:10 | Issue:SUPPLEMENT 1 Page(s): 29-30

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Title

GENETIC MODIFICATION OF HUMAN EMBRYONIC STEM CELLS

Author(s)

CUI W.

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Abstract

The isolation and culture of human embryonic stem cells (hESCs) has opened up new opportunities not only for regenerative medicine and other biomedical applications but also for the study of early human development, signaling pathway networks and mechanisms of human diseases. However, it is remain unclear about the factors important for the maintenance of undifferentiated hESCs in vitro and factors /signaling pathways leading hESCs differentiation to specific lineages. Genetic modification of hESCs will facilitate our investigation to achieve thesegoals. For example, incorporation of fluorescent reporter genes in a lineage specific expression pattern will enable more effective screening to identify molecules regulating specific cell fate commitment. Ectopic expression, or silencing, of key developmental genes/ will enhance our understanding their function in hESCs self-renewal or differentiation. We have generated hESCs reporter cell lines expressing green fluorescent protein (GFP) under the control of ES cell (e.g. Oct4) or lineage specific (e.g. a-fetoprotein, AFP for endodermal lineage) promoters using either chemical transfection or lentiviral transduction techniques. Using these reporter cell lines, we have compared effect of bFGF in regulation of human ES cell self-renewal, studied Oct4 expression in regulation of hESCs differentiation and development of better system to differentiate hESCs to hepatic cell fate.

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APA: Copy

CUI, W.. (2008). GENETIC MODIFICATION OF HUMAN EMBRYONIC STEM CELLS. CELL JOURNAL (YAKHTEH), 10(SUPPLEMENT 1), 29-30. SID. https://sid.ir/paper/542720/en

Vancouver: Copy

CUI W.. GENETIC MODIFICATION OF HUMAN EMBRYONIC STEM CELLS. CELL JOURNAL (YAKHTEH)[Internet]. 2008;10(SUPPLEMENT 1):29-30. Available from: https://sid.ir/paper/542720/en

IEEE: Copy

W. CUI, “GENETIC MODIFICATION OF HUMAN EMBRYONIC STEM CELLS,” CELL JOURNAL (YAKHTEH), vol. 10, no. SUPPLEMENT 1, pp. 29–30, 2008, [Online]. Available: https://sid.ir/paper/542720/en

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