ORAL CLONIDINE PREMEDICATION DECREASES INTRAOPERATIVE BLEEDING IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY

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JAB ALAMELI M.; HASHEMI J.; HASHEMI M.; SOLTANI H.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2005 | Volume:10 | Issue:1 Page(s): 25-30

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Title

ORAL CLONIDINE PREMEDICATION DECREASES INTRAOPERATIVE BLEEDING IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY

Author(s)

JAB ALAMELI M. | HASHEMI J. | HASHEMI M. | SOLTANI H. | Issue Writer Certificate

Keywords

SINUS SURGERY

ENDOSCOPY

CLONIDINE

HYDRALAZINE

FENTANYL

BLEEDING

Abstract

Background: The antihypertensive drug, CLONIDINE, is a centrally acting alpha 2 agonist, useful as a premedication because of its sedative and analgesic properties. We examined the effect of CLONIDINE given as an oral premedication in producing a bloodless surgical field in patients undergoing endoscopic SINUS SURGERY. We also evaluated the relation between BLEEDING volume and consumption of FENTANYL and HYDRALAZINE to control hypotension. Methods: This prospective double - blinded clinical trial was performed on 113 patients (ASA I, ASA II). Fifty-two patients received oral CLONIDINE (5 μ g/kg) while the other 61 patients received placebo. During general anesthesia, the hemodynamic endpoint of the anesthetic management was maintenance of hypotension (MAP) at 70 mmHg for producing a bloodless surgical field. The direct control of MAP was attained with inspired concentration increments of halothane up to maximum of 1.5 vol % as needed. When it was unsuccessful, an intravenous FENTANYL bolus of 2 μ g/kg was also added. When both drugs failed, HYDRALAZINE , was given intravenously as a bolus and intermittently, 0.1mg/kg up to a maximum dose of 40 mg. Intraoperative BLEEDING was assessed on a six – point scale from 0 (= no BLEEDING) to 5 (= severe BLEEDING). Data were compared with chisquare test, fisher's exact test and Student t-test. Results: There was less BLEEDING volume in the CLONIDINE group (mean ± SD) than in the placebo group (144 ± 75 Vs 225 ± 72 ml, P<0.05). Frequency of BLEEDING severity scores 3 and 4 (troublesome with repeated suction) were lower in the CLONIDINE group than in the placebo group (12% Vs 35%, P< 0.05). FENTANYL requirement was significantly lower (112 ± 18 Vs 142 ± 21μ g, P < 0.05) in the CLONIDINE group. HYDRALAZINE requirement was significantly lower (0.45 ± 1.68 Vs 2.67 ± 4.33 mg, P<0.05) as well. Conclusion: Premedication with oral CLONIDINE reduces BLEEDING in endoscopic SINUS SURGERY and also decreases FENTANYL, and HYDRALAZINE consumption for controlling hypotension.

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APA: Copy

JAB ALAMELI, M., HASHEMI, J., HASHEMI, M., & SOLTANI, H.. (2005). ORAL CLONIDINE PREMEDICATION DECREASES INTRAOPERATIVE BLEEDING IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 10(1), 25-30. SID. https://sid.ir/paper/545855/en

Vancouver: Copy

JAB ALAMELI M., HASHEMI J., HASHEMI M., SOLTANI H.. ORAL CLONIDINE PREMEDICATION DECREASES INTRAOPERATIVE BLEEDING IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2005;10(1):25-30. Available from: https://sid.ir/paper/545855/en

IEEE: Copy

M. JAB ALAMELI, J. HASHEMI, M. HASHEMI, and H. SOLTANI, “ORAL CLONIDINE PREMEDICATION DECREASES INTRAOPERATIVE BLEEDING IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 10, no. 1, pp. 25–30, 2005, [Online]. Available: https://sid.ir/paper/545855/en

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