CORRELATION OF BCL-2 AND COX-2 EXPRESSION IN ORAL LICHEN PLANUS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAGHAVI N.; MAHDAVI N.; SHAHLA M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ISLAMIC DENTAL ASSOCIATION OF IRAN (MAJALLAH-I-DANDANPIZISHKI) Year:2014 | Volume:26 | Issue:1 Page(s): 51-58

Download Full-Text

Persian Verion

View:

786

Download:

Cites:

Information Journal Paper

Title

CORRELATION OF BCL-2 AND COX-2 EXPRESSION IN ORAL LICHEN PLANUS

Author(s)

TAGHAVI N. | MAHDAVI N. | SHAHLA M. | Issue Writer Certificate

Keywords

ORAL LICHEN PLANUSQ1

COX-2Q2

BCL-2Q2

Abstract

Background and Aim: Lichen planus is a common immune-mediated disease that is associated with an increased risk of malignant transformation in the oral cavity. Synchronous up-regulation of COX-2 and down-regulation of BCL-2 have been demonstrated in some malignancies. The aim of this study was to assess the correlation between COX-2 and BCL-2 expression and their role in dysplastic changes of ORAL LICHEN PLANUS (OLP ). Materials and Methods: This study was performed on 47 paraffin blocks with the diagnosis of OLP and 16 blocks with the diagnosis of focal fibrous hyperplasia (control group). Immunohistochemical staining was performed using antibodies against COX-2 and BCL-2. Spearman’s rank correlation coefficient and Mann-Whitney test were used for data analysis.Results: A significant correlation was observed between the intensity of sub-epithelial inflammation and the severity of basal cell layer degeneration (P=0.048). Significant up-regulation of BCL-2 and COX-2 was detected in sub-epithelial inflammatory infiltration (P<0.001, P=0,003). The amount and intensity of BCL-2 and COX-2 expression were significantly correlated in sub-epithelial lymphocytic infiltration (P=0.013, P=0.019 ).Conclusion: Our findings indicated the effective role of BCL-2 expression in decreasing the apoptosis in the inflammator y infiltrate unlike the epithelium. The significant correlation of the intensity of BCL-2 expression in the epithelium and the sub-epithelial inflammatory infiltrate with COX-2 expression and also the correlation of the intensity of inflammation with the severity of basal layer hydropic degeneration may imply that these two markers can induce malignant transformation in the affected epithelium in an indirect manner by the continuation of inflammation and activation of carcinogenic mechanisms.

Cites

No record.

References

No record.

Cite

APA: Copy

TAGHAVI, N., MAHDAVI, N., & SHAHLA, M.. (2014). CORRELATION OF BCL-2 AND COX-2 EXPRESSION IN ORAL LICHEN PLANUS. JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI), 26(1), 51-58. SID. https://sid.ir/paper/54629/en

Vancouver: Copy

TAGHAVI N., MAHDAVI N., SHAHLA M.. CORRELATION OF BCL-2 AND COX-2 EXPRESSION IN ORAL LICHEN PLANUS. JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI)[Internet]. 2014;26(1):51-58. Available from: https://sid.ir/paper/54629/en

IEEE: Copy

N. TAGHAVI, N. MAHDAVI, and M. SHAHLA, “CORRELATION OF BCL-2 AND COX-2 EXPRESSION IN ORAL LICHEN PLANUS,” JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI), vol. 26, no. 1, pp. 51–58, 2014, [Online]. Available: https://sid.ir/paper/54629/en

Related Journal Papers