A COMPARATIVE EVALUATION ON E-CADHERIN EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA WITH AND WITHOUT REGIONAL LYMPH NODE METASTASIS

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MOHTASHAM N.; OMIDI A.; KAMYAB HESARI K.; SHAKERI M.T.

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Paper Information

Journal: JOURNAL OF ISLAMIC DENTAL ASSOCIATION OF IRAN (MAJALLAH-I-DANDANPIZISHKI) Year:2006 | Volume:18 | Issue:1 (58) Page(s): 56-61

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Title

A COMPARATIVE EVALUATION ON E-CADHERIN EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA WITH AND WITHOUT REGIONAL LYMPH NODE METASTASIS

Author(s)

MOHTASHAM N. | OMIDI A. | KAMYAB HESARI K. | SHAKERI M.T. | Issue Writer Certificate

Keywords

ORAL SQUAMOUS CELL CARCINOMAQ3

EQ3

CADHERINQ3

METASTASISQ2

IMMUNOHISTOCHEMISTRYQ2

Abstract

Background and Aim: E-cadherin is a cell to cell adhesion molecule and a reduction in its Expression is an important step in the progression of lots of Epithelial cancers. Regional lymph node METASTASIS ia an important prognostic indicator in cancers. The aim of this study was to Evaluate and compare E-cadherin Expression in ORAL SQUAMOUS CELL CARCINOMA with and without regional lymph node METASTASIS.Materials and Methods: In this retrospective analytic - descriptive study, the Expression of E - CADHERIN was Evaluated in 34 formalin- fixed, paraffin- Embedded specimens of oral S.C.C. and regional lymph node METASTASIS, half of them with and the other half without METASTASIS, using IMMUNOHISTOCHEMISTRY. The regional anti - body was E-cadherin which was detected by Biotinylated link and Streptoavidin methods. Wilcoxon test was used to compare the E - CADHERIN incidence in the primary tumor and Mann - Whitney non-parametric test was used to compare its incidence in S.C.C without and with METASTASIS tumor.Results: In normal squamous Epithelium, E - CADHERIN was Expressed uniformity at the cell membrane, abnormal E - CADHERIN Expression with loss of membranous localization was found in 82% of specimens and a significantly greater reduction in Expression levels of E-cadherin was found in METASTASIS group as compared with non - metastatic group (P=0.003, 0.007). There was not any significant difference between primary turnors in two groups (P=0.60). A relationship was found between abnormal Expression of E-cadherin and the differentiation of oral S.C.C (P<0.01).Conclusion: Abnormal Expression of E-cadherin is associated with differentiation, progression and metastatic of oral S.C.C.

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References

تعیین بروز نشانگر E-Cadherin در کار سینوم سلولهای سنگفرشی مخاط دهان و ارتباط با شاخصهای هیستوپاتولوژیک

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APA: Copy

MOHTASHAM, N., OMIDI, A., KAMYAB HESARI, K., & SHAKERI, M.T.. (2006). A COMPARATIVE EVALUATION ON E-CADHERIN EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA WITH AND WITHOUT REGIONAL LYMPH NODE METASTASIS. JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI), 18(1 (58)), 56-61. SID. https://sid.ir/paper/54844/en

Vancouver: Copy

MOHTASHAM N., OMIDI A., KAMYAB HESARI K., SHAKERI M.T.. A COMPARATIVE EVALUATION ON E-CADHERIN EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA WITH AND WITHOUT REGIONAL LYMPH NODE METASTASIS. JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI)[Internet]. 2006;18(1 (58)):56-61. Available from: https://sid.ir/paper/54844/en

IEEE: Copy

N. MOHTASHAM, A. OMIDI, K. KAMYAB HESARI, and M.T. SHAKERI, “A COMPARATIVE EVALUATION ON E-CADHERIN EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA WITH AND WITHOUT REGIONAL LYMPH NODE METASTASIS,” JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI), vol. 18, no. 1 (58), pp. 56–61, 2006, [Online]. Available: https://sid.ir/paper/54844/en

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