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Information Journal Paper

Title

THE COMPARATIVE STUDY OF BINDING CHARACTERISTICS OF COBALT AND IRON TO HUMAN SERUM TRANSFERRIN

Pages

  1-5

Abstract

 Background: COBALT (Co) is an essential trace element. Available data suggest an interaction between COBALT and other elements.In this study the characteristics of Co and iron (Fe) bindings to human apo-TRANSFERRIN (apo-tf) have been investigated and compared.Methods: Using spectrophotometer titration and equilibrium dialysis techniques, the bindings of Co (III) and Fe (III) to apo-tf were studied.Results: Both Fe (Ill) and Co (III) as complexes with citric acid (1:20) were taken up by apo-tf, forming complexes with the maximum absorbance's at 465nm and 360 nm respectively.Conclusion: The binding of iron to apo-tf at 465 nm was reduced by 20% when 225 nmole/ml of COBALT was added to the reaction mixture. The binding constant of iron to apo-tf was calculated using scatchard plot analysis and it was 22x109M-.The addition of COBALT (III), 200 µg/l to the outside of the dialysis sac reduced iron Uptake by 30%. The binding constant of Co (III) to apo-tf was also calculated and it was 3x109M-1.

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    APA: Copy

    MOSHTAGHI, A.A., BADIEI, AKBAR, & MOHAMMADIAN, T.. (2004). THE COMPARATIVE STUDY OF BINDING CHARACTERISTICS OF COBALT AND IRON TO HUMAN SERUM TRANSFERRIN. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 9(6), 1-5. SID. https://sid.ir/paper/548856/en

    Vancouver: Copy

    MOSHTAGHI A.A., BADIEI AKBAR, MOHAMMADIAN T.. THE COMPARATIVE STUDY OF BINDING CHARACTERISTICS OF COBALT AND IRON TO HUMAN SERUM TRANSFERRIN. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2004;9(6):1-5. Available from: https://sid.ir/paper/548856/en

    IEEE: Copy

    A.A. MOSHTAGHI, AKBAR BADIEI, and T. MOHAMMADIAN, “THE COMPARATIVE STUDY OF BINDING CHARACTERISTICS OF COBALT AND IRON TO HUMAN SERUM TRANSFERRIN,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 9, no. 6, pp. 1–5, 2004, [Online]. Available: https://sid.ir/paper/548856/en

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