ALTERATION IN ANTIOXIDANT CAPACITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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HAKHAMANESHI M.S.; MESBAH NAMIN S.A.R.; HOUSHMAND M.; SAHEBGHADAM LOTFI A.

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Journal Paper

Paper Information

Journal: TANAFFOS Year:2007 | Volume:6 | Issue:4 Page(s): 13-17

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Information Journal Paper

Title

ALTERATION IN ANTIOXIDANT CAPACITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Author(s)

HAKHAMANESHI M.S. | MESBAH NAMIN S.A.R. | HOUSHMAND M. | SAHEBGHADAM LOTFI A. | Issue Writer Certificate

Keywords

COPD

OXIDATIVE STRESS

FERRIC REDUCING ABILITY OF PLASMA (FRAP)

COPD

Abstract

Background: Chronic obstructive pulmonary disease (COPO) is a major public health problem that needs greater attention. Variability in the susceptibility to develop COPO is related to both genetic and environmental factors. OXIDATIVE STRESS and inflammation are the major hallmarks of COPO and antioxidant status can be used as a biomarker to assess the risk of chronic diseases.Materials and Methods: We used the FRAP (ferric reducing ability of plasma) assay as a simple and powerful test for determination of the total antioxidant capacity of plasma of patients and normal subjects. The patients were selected by cross-sectional method. The mean average age ±SD of normal subjects and patients was 56±4 and 60±2 years respectively. The spectrophotometer method was used for this assay.Results: The means of the FRAP assays in the patients were higher (about twice) than those of normal subjects. The differences were significant (p<0.01).Conclusion: The high levels of antioxidant capacity in the patient group indicated that the antioxidant defense system had been activated due to the OXIDATIVE STRESS and hypoxic condition. A though, FRAP assay can probably be used for demarcation of severity and risk of developing COPO, clinical follow-up and further investigation are required for the assessment of this hypothesis.

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APA: Copy

HAKHAMANESHI, M.S., MESBAH NAMIN, S.A.R., HOUSHMAND, M., & SAHEBGHADAM LOTFI, A.. (2007). ALTERATION IN ANTIOXIDANT CAPACITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. TANAFFOS, 6(4), 13-17. SID. https://sid.ir/paper/552031/en

Vancouver: Copy

HAKHAMANESHI M.S., MESBAH NAMIN S.A.R., HOUSHMAND M., SAHEBGHADAM LOTFI A.. ALTERATION IN ANTIOXIDANT CAPACITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. TANAFFOS[Internet]. 2007;6(4):13-17. Available from: https://sid.ir/paper/552031/en

IEEE: Copy

M.S. HAKHAMANESHI, S.A.R. MESBAH NAMIN, M. HOUSHMAND, and A. SAHEBGHADAM LOTFI, “ALTERATION IN ANTIOXIDANT CAPACITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE,” TANAFFOS, vol. 6, no. 4, pp. 13–17, 2007, [Online]. Available: https://sid.ir/paper/552031/en

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