مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

APOPTOSIS: FROM SIGNALLING PATHWAYS TO THERAPEUTIC TOOLS

Pages

  121-142

Abstract

 APOPTOSIS or programmed cell death is a gene regulated phenomenon which is important in both physiological and pathological conditions. It is characterized by distinct morphological features including chromatin condensation, cell and nuclear shrinkage, membrane blebbing and oligonucleosomal DNA fragmentation. Although, two major apoptotic pathways including 1) the death receptor (extrinsic) and 2) mitochondrial (intrinsic) pathway have been identified, recently endoplasmic reticulum and lysosomal pathways have been also recognized. Depending on both the cell type and the initiating factor, distinct pathways are activated. The pathways share a common final phase of APOPTOSIS, consisting of activation of the executioner caspases and dismantling of substrates critical for cell survival. The important regulatory mechanisms include death receptors, caspases, mitochondria and Bcl-2 family proteins. Modulating of APOPTOSIS is a novel therapeutic strategy in treatment of different diseases. These include situations with unwanted cell accumulation (cancer) and failure to diminish aberrant cells (autoimmune diseases) or diseases with an inappropriate cell loss (heart failure, stroke, AIDS and NEURODEGENERATIVE DISEASES). Modulation of APOPTOSIS is a novel therapeutic strategy in treatment of different diseases. Many approaches including gene therapy, antisense strategies and numerous apoptotic drugs to target specific apoptotic regulators, are currently being developed. The goal of this review is to provide a general overview of current knowledge on the process of APOPTOSIS including morphology, biochemistry, signaling as well as a discussion of APOPTOSIS in diseases and effective therapy.

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    • Cite

    APA: Copy

    MOUSAVI, SEYED HADI, TAYARANI NAJARAN, Z., & HERSEY, P.. (2008). APOPTOSIS: FROM SIGNALLING PATHWAYS TO THERAPEUTIC TOOLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 11(3 (39)), 121-142. SID. https://sid.ir/paper/553372/en

    Vancouver: Copy

    MOUSAVI SEYED HADI, TAYARANI NAJARAN Z., HERSEY P.. APOPTOSIS: FROM SIGNALLING PATHWAYS TO THERAPEUTIC TOOLS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2008;11(3 (39)):121-142. Available from: https://sid.ir/paper/553372/en

    IEEE: Copy

    SEYED HADI MOUSAVI, Z. TAYARANI NAJARAN, and P. HERSEY, “APOPTOSIS: FROM SIGNALLING PATHWAYS TO THERAPEUTIC TOOLS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 11, no. 3 (39), pp. 121–142, 2008, [Online]. Available: https://sid.ir/paper/553372/en

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