EFFECTS OF SAFFRON AND ITS ACTIVE CONSTITUENTS, CROCIN AND SAFRANAL, ON PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN DIABETIC AND NONDIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KIANBAKHT S.; MOZAFARI K.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Medicinal Plants Year:2009 | Volume:8 | Issue:SUPPLEMENT 5 Page(s): 30-38

Download Full-Text

View:

979

Download:

558

Cites:

Information Journal Paper

Title

EFFECTS OF SAFFRON AND ITS ACTIVE CONSTITUENTS, CROCIN AND SAFRANAL, ON PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN DIABETIC AND NONDIABETIC RATS

Author(s)

KIANBAKHT S. | MOZAFARI K. | Issue Writer Certificate

Keywords

SAFFRON

CROCIN

SAFRANAL

GASTRIC ULCERS

DIABETES MELLITUS

RAT

Abstract

Background: SAFFRON is the dried stigmata of the flowers of SAFFRON (Crocus sativus L., Iridaceae). SAFFRON is well known for the treatment of gastric disorders in traditional medicine.Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of SAFFRON and its active constituents CROCIN and SAFRANAL as compared with omeprazole against gastric ulcer induced by indomethacin in non-diabetic and streptozocin diabetic RATs were studied.Methods: The effects of pretreatment with SAFFRON extract (25, 100 or 250 mg/kg, p.o.), CROCIN (2.5, 5 or 10 mg/kg, p.o.) and SAFRANAL (0.25, 2, 5 ml/kg, p.o.) and omeprazole (30 mg/kg, p.o.) 30 min before administration of indomethacin (40 mg/kg, p.o. in non-diabetic RATs and 15 mg/kg, p.o. in diabetic RATs) on gastric lesions, increase of lipid peroxidation and decrease of glutathione levels induced by indomethacin in non-diabetic and diabetic RATs were evaluated.Results: SAFFRON extract, CROCIN, SAFRANAL and omeprazol prevented the gastric lesions, increase of lipid peroxidation and decrease of glutathione levels induced by indomethacin in non-diabetic and diabetic RATs as compared with the control group (P<0.01). The effects of SAFFRON extract, CROCIN and SAFRANAL on the gastric ulcer index, lipid peroxidation and glutathione levels were comparable to omeprazole.Conclusions: SAFFRON, CROCIN and SAFRANAL may prevent the gastric mucosa damage due to their antioxidant properties by increasing the gluthatione levels and diminishing the lipid peroxidation in the RAT gastric mucosa.

Cites

A REVIEW ON THE EFFECTS OF SAFFRON EXTRACT AND ITS CONSTITUENTS ON FACTORS RELATED TO NEUROLOGIC, CARDIOVASCULAR AND GASTROINTESTINAL DISEASES

References

Cite

APA: Copy

KIANBAKHT, S., & MOZAFARI, K.. (2009). EFFECTS OF SAFFRON AND ITS ACTIVE CONSTITUENTS, CROCIN AND SAFRANAL, ON PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN DIABETIC AND NONDIABETIC RATS. JOURNAL OF MEDICINAL PLANTS, 8(SUPPLEMENT 5), 30-38. SID. https://sid.ir/paper/555089/en

Vancouver: Copy

KIANBAKHT S., MOZAFARI K.. EFFECTS OF SAFFRON AND ITS ACTIVE CONSTITUENTS, CROCIN AND SAFRANAL, ON PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN DIABETIC AND NONDIABETIC RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2009;8(SUPPLEMENT 5):30-38. Available from: https://sid.ir/paper/555089/en

IEEE: Copy

S. KIANBAKHT, and K. MOZAFARI, “EFFECTS OF SAFFRON AND ITS ACTIVE CONSTITUENTS, CROCIN AND SAFRANAL, ON PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN DIABETIC AND NONDIABETIC RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 8, no. SUPPLEMENT 5, pp. 30–38, 2009, [Online]. Available: https://sid.ir/paper/555089/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops