ASSOCIATION OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM WITH PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA

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OMRANI M.D.; BAZARGANI S.; BAGHERI MORTEZA; YAZDANNEZHAD H.

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Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2009 | Volume:14 | Issue:4 Page(s): 217-222

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Title

ASSOCIATION OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM WITH PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA

Author(s)

OMRANI M.D. | BAZARGANI S. | BAGHERI MORTEZA | YAZDANNEZHAD H. | Issue Writer Certificate

Keywords

PROSTATE CANCER

BENIGN PROSTATIC HYPERPLASIA

COMT 158VAL/MET POLYMORPHISM

Abstract

BACKGROUND: A single nucleotide variation within catechol-o-methyl transferase (COMT) gene may alter the COMT enzyme activity level. Polymorphism of Val158Met in the COMT gene has been related to malignancy. In this regard, a study was carried out to find a possible association between the COMT gene polymorphism in patients with sporadic PROSTATE CANCER (PCa) and BENIGN PROSTATIC HYPERPLASIA (BPH).METHODS: All types of COMT158 Val/Met polymorphism were carried out using ASO-PCR method in 41 patients with PROSTATE CANCER, 193 patients with BENIGN PROSTATIC HYPERPLASIA and 107 healthy male individuals.RESULTS: The results of this study showed that the frequency of low producer allele A at codon 158 of the COMT gene is significantly different in BPH group compared to normal male control group (OR, 95% CI, p value 1.95: 1.46, 2.44, 0.021, respectively). However no significant difference was noticed when the comparison was made between PROSTATE CANCER group and normal male control group and also between BPH and PCa groups.CONCLUSIONS: Decreased level of catechol-o-methyl transferase gene activity may play a possible role in BENIGN PROSTATIC HYPERPLASIA development but not in PROSTATE CANCER. Increased level of COMT gene activity has a protective role against BPH.

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APA: Copy

OMRANI, M.D., BAZARGANI, S., BAGHERI, MORTEZA, & YAZDANNEZHAD, H.. (2009). ASSOCIATION OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM WITH PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 14(4), 217-222. SID. https://sid.ir/paper/555105/en

Vancouver: Copy

OMRANI M.D., BAZARGANI S., BAGHERI MORTEZA, YAZDANNEZHAD H.. ASSOCIATION OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM WITH PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2009;14(4):217-222. Available from: https://sid.ir/paper/555105/en

IEEE: Copy

M.D. OMRANI, S. BAZARGANI, MORTEZA BAGHERI, and H. YAZDANNEZHAD, “ASSOCIATION OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM WITH PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 14, no. 4, pp. 217–222, 2009, [Online]. Available: https://sid.ir/paper/555105/en

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