SHORT COMMUNICATION: ANTI-ANGIOGENIC ACTIVITY OF FICUS CARICA LATEX EXTRACT ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

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MOSTAFAEI ALI; MANSOURI KAMRAN; NOROUZNEZHAD A.H.; MOHAMMADI MOTLAGH H.R.

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2011 | Volume:12 | Issue:4 (48) Page(s): 525-528

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Title

SHORT COMMUNICATION: ANTI-ANGIOGENIC ACTIVITY OF FICUS CARICA LATEX EXTRACT ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

Author(s)

MOSTAFAEI ALI | MANSOURI KAMRAN | NOROUZNEZHAD A.H. | MOHAMMADI MOTLAGH H.R. | Issue Writer Certificate

Keywords

ANTI-ANGIOGENESIS

ANTI-PROLIFERATIVE

UMBILICAL CORD

ENDOTHELIAL CELL

Abstract

Angiogenesis, the formation of new blood vessels, is a key process in cancer development and metastasis. In this study, the anti-angiogenic and ANTI-PROLIFERATIVE potentials of Ficus carica latex extract have been investigated using human umbilical vein ENDOTHELIAL CELLs (HUVECs).Different doses of latex extract were prepared and added to a three-dimensional culture of HUVEC in a collagen matrix. After 3-5 days of treatment, the anti-angiogenic effects of the extracts were monitored microscopically. For the anti-proliferation assay, different doses of the extracts were examined on HUVECs.The results clearly indicated that latex extract could inhibit proliferation and capillary tube formation of HUVECs in a dose-dependent manner at the range of 100-400 mg/ml. In addition, the extract was not cytotoxic up to 450 mg/ml as assessed by trypan blue and lactate dehydrogenase (LDH) cytotoxicity assays.It is concluded that latex extracts of F. carica contain strong anti-angiogenic and ANTI-PROLIFERATIVE activities. Our data indicates that latex extract could be a candidate as a potential agent for the prevention of angiogenesis in cancer and other chronic disorders.

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APA: Copy

MOSTAFAEI, ALI, MANSOURI, KAMRAN, NOROUZNEZHAD, A.H., & MOHAMMADI MOTLAGH, H.R.. (2011). SHORT COMMUNICATION: ANTI-ANGIOGENIC ACTIVITY OF FICUS CARICA LATEX EXTRACT ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. CELL JOURNAL (YAKHTEH), 12(4 (48)), 525-528. SID. https://sid.ir/paper/556656/en

Vancouver: Copy

MOSTAFAEI ALI, MANSOURI KAMRAN, NOROUZNEZHAD A.H., MOHAMMADI MOTLAGH H.R.. SHORT COMMUNICATION: ANTI-ANGIOGENIC ACTIVITY OF FICUS CARICA LATEX EXTRACT ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS. CELL JOURNAL (YAKHTEH)[Internet]. 2011;12(4 (48)):525-528. Available from: https://sid.ir/paper/556656/en

IEEE: Copy

ALI MOSTAFAEI, KAMRAN MANSOURI, A.H. NOROUZNEZHAD, and H.R. MOHAMMADI MOTLAGH, “SHORT COMMUNICATION: ANTI-ANGIOGENIC ACTIVITY OF FICUS CARICA LATEX EXTRACT ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS,” CELL JOURNAL (YAKHTEH), vol. 12, no. 4 (48), pp. 525–528, 2011, [Online]. Available: https://sid.ir/paper/556656/en

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