COMPARING SEMINAL PLASMA BIOMARKERS BETWEEN NORMOSPERMIC AND AZOOSPERMIC MEN

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SABETIAN S.; ARDAKANI A.M.; HOJAT MAHSHID; AKHOUNDI MOHAMMAD MAHDI; SOLTAN GHORAEI HALEH; AMIR JANATI N.; LAKPOUR N.; SADEGHI MOHAMMAD REZA

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Journal: Journal of Reproduction & Infertility Year:2010 | Volume:11 | Issue:1 (42) Page(s): 39-46

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Title

COMPARING SEMINAL PLASMA BIOMARKERS BETWEEN NORMOSPERMIC AND AZOOSPERMIC MEN

Author(s)

Keywords

ANTI-MULLERIAN HORMONE

AZOOSPERMIA

FRUCTOSE

INHIBIN B

MALE INFERTILITY

NEUTRAL ALPHA GLUCOSIDASE

SEMINAL PLASMA

SPERMATOGENESIS

Abstract

Introduction: AZOOSPERMIA affects more than 10%-15% of infertile male subjects attending infertilty clinics. At present, testicular biopsy is the golden standard procedure for evaluating SPERMATOGENESIS status in men with AZOOSPERMIA. Semen collection and analysis is a non-invasive method and has proven to be valuable in the evaluation of SPERMATOGENESIS. Identification of SEMINAL PLASMA markers with testicular or extra-testicular origins have a great value in predicting the prescence of sperm in testicular tissue and presumptive cause of AZOOSPERMIA. The aim of this study was to find such markers by comparing the content of SEMINAL PLASMA using different methods in normospermic and azoospermic men. Matherials and Methods: Semen samples were collected from 200 men attending Avicenna Infertility Clinic (AIC) in Tehran, Iran. Semen samples were analysed according to WHO guidlines. The subjects were divided into two groups: normospermic (n=100; group one) and azoospermic men (n=100; group two) according to semen analysis results. SEMINAL PLASMA was separated by high speed centrifuagation and stored in -20oC. Four markers including FRUCTOSE, NEUTRAL ALPHA GLUCOSIDASE (NaG), INHIBIN B and anti-Müllerian hormone (AMH) were measured in SEMINAL PLASMA. FRUCTOSE and NaG were evaluated by spectrophotometry, while INHIBIN B and AMH were assessed by ELISA method. The SPERMATOGENESIS status in the azoospermic group was evaluated by histopathological method following testicular biopsy.Results: FRUCTOSE concentration showed no difference between the two groups. However, it was significantly correlated with sperm count (p<0.01, r=-0.408). SEMINAL PLASMA INHIBIN B (OR: 1.01; 95%: CI: 1.005-1.016), AMH (OR: 1.63; 95% CI: 1.17-2.28) and NaG, (OR: 1.07; 95% CI: 1.04-1.1) levels were higher in normospermic subjects compared to azoo-spermic men. There were significant differences in INHIBIN B and AMH concentrations between the two groups based on the presence or absence of mature sperm in testicular biopsies (p<0.01). INHIBIN B concentration was positively correlated with sperm count in the normo-spermic group, however, NaG concentration correlated with sperm count of normospermic men (p<0.01, r=0.345) and the subjects’age in both groups.Conclusion: INHIBIN B and AMH were correlated with the presence of sperm in testicular tissue samples. According to non-specific changes in INHIBIN B and AMH concentrations, identifica-tion of more specific molecular markers in SEMINAL PLASMA to definitely evaluate the status of SPERMATOGENESIS is recommended.

Cites

FOURIER TRANSFORM INFRARED SPECTROSCOPY: A POTENTIAL TECHNIQUE FOR NONINVASIVE DETECTION OF SPERMATOGENESIS

References

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APA: Copy

SABETIAN, S., ARDAKANI, A.M., HOJAT, MAHSHID, AKHOUNDI, MOHAMMAD MAHDI, SOLTAN GHORAEI, HALEH, AMIR JANATI, N., LAKPOUR, N., & SADEGHI, MOHAMMAD REZA. (2010). COMPARING SEMINAL PLASMA BIOMARKERS BETWEEN NORMOSPERMIC AND AZOOSPERMIC MEN. JOURNAL OF REPRODUCTION AND INFERTILITY, 11(1 (42)), 39-46. SID. https://sid.ir/paper/557066/en

Vancouver: Copy

SABETIAN S., ARDAKANI A.M., HOJAT MAHSHID, AKHOUNDI MOHAMMAD MAHDI, SOLTAN GHORAEI HALEH, AMIR JANATI N., LAKPOUR N., SADEGHI MOHAMMAD REZA. COMPARING SEMINAL PLASMA BIOMARKERS BETWEEN NORMOSPERMIC AND AZOOSPERMIC MEN. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2010;11(1 (42)):39-46. Available from: https://sid.ir/paper/557066/en

IEEE: Copy

S. SABETIAN, A.M. ARDAKANI, MAHSHID HOJAT, MOHAMMAD MAHDI AKHOUNDI, HALEH SOLTAN GHORAEI, N. AMIR JANATI, N. LAKPOUR, and MOHAMMAD REZA SADEGHI, “COMPARING SEMINAL PLASMA BIOMARKERS BETWEEN NORMOSPERMIC AND AZOOSPERMIC MEN,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 11, no. 1 (42), pp. 39–46, 2010, [Online]. Available: https://sid.ir/paper/557066/en

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