INTEGRASE MINUS LENTIVIRAL VECTOR: A SUITABLE VECTOR FOR β THALASSEMIA GENE TARGETING

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NOURI INANLOU DAVOUD; YAKHCHALI B.; KHANAHMAD H.; GARDANEH M.; MOVASAGH HESAM; FARAZMANDFAR TOURAJ; FEYZ BARAZANDEH A.; ZEYNALI SIROUS

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Journal: IRANIAN JOURNAL OF MEDICAL HYPOTHESES AND IDEAS Year:2009 | Volume:3 | Issue:3 Page(s): 0-0

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Title

INTEGRASE MINUS LENTIVIRAL VECTOR: A SUITABLE VECTOR FOR β THALASSEMIA GENE TARGETING

Author(s)

Keywords

β-THALASSEMIA

LENTIVIRAL VECTORS

INTEGRASE MINUS

GENE TARGETING

Abstract

b-Thalassemia is a congenital disorder caused by mutation in b-globin gene. The current therapies to treat b-thalassemia have many complications and limitations necessitating development of new curative methods. Recently, a great attention has been paid to gene therapy of b-thalassemia using LENTIVIRAL VECTORS. Although insertion of transgene into these vectors direct regulated expression of b-globin at therapeutic levels, lentiviruses unfavorably are integrated into the host-cell chromosomes. Conse-quently there is a key challenge for clinical application of LENTIVIRAL VECTORS in treat-ment of b-thalassemia. In order to overcome this problem, we have presented a novel hypothesis based on homologous recombination technology including a single negative double positive selection strategy for b-globin GENE TARGETING. Because of no effect on other regions of the host genome, GENE TARGETING with INTEGRASE MINUS LENTIVIRAL VECTORS seems an appropriate and safe method to correct genetic defects like b-thalassemia.

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APA: Copy

NOURI INANLOU, DAVOUD, YAKHCHALI, B., KHANAHMAD, H., GARDANEH, M., MOVASAGH, HESAM, FARAZMANDFAR, TOURAJ, FEYZ BARAZANDEH, A., & ZEYNALI, SIROUS. (2009). INTEGRASE MINUS LENTIVIRAL VECTOR: A SUITABLE VECTOR FOR β THALASSEMIA GENE TARGETING. IRANIAN JOURNAL OF MEDICAL HYPOTHESES AND IDEAS, 3(3), 0-0. SID. https://sid.ir/paper/557770/en

Vancouver: Copy

NOURI INANLOU DAVOUD, YAKHCHALI B., KHANAHMAD H., GARDANEH M., MOVASAGH HESAM, FARAZMANDFAR TOURAJ, FEYZ BARAZANDEH A., ZEYNALI SIROUS. INTEGRASE MINUS LENTIVIRAL VECTOR: A SUITABLE VECTOR FOR β THALASSEMIA GENE TARGETING. IRANIAN JOURNAL OF MEDICAL HYPOTHESES AND IDEAS[Internet]. 2009;3(3):0-0. Available from: https://sid.ir/paper/557770/en

IEEE: Copy

DAVOUD NOURI INANLOU, B. YAKHCHALI, H. KHANAHMAD, M. GARDANEH, HESAM MOVASAGH, TOURAJ FARAZMANDFAR, A. FEYZ BARAZANDEH, and SIROUS ZEYNALI, “INTEGRASE MINUS LENTIVIRAL VECTOR: A SUITABLE VECTOR FOR β THALASSEMIA GENE TARGETING,” IRANIAN JOURNAL OF MEDICAL HYPOTHESES AND IDEAS, vol. 3, no. 3, pp. 0–0, 2009, [Online]. Available: https://sid.ir/paper/557770/en

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