PROTECTIVE EFFECT OF URTICA DIOICAON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS

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GOL ALIPOUR M.J.; MOHAMMAD GHARAAVI ANEH; GHAFARI SORAYA; AZARHOUSH R.

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Paper Information

Journal: JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS) Year:2009 | Volume:10 | Issue:6 (47) Page(s): 43-22

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Title

PROTECTIVE EFFECT OF URTICA DIOICAON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS

Author(s)

GOL ALIPOUR M.J. | MOHAMMAD GHARAAVI ANEH | GHAFARI SORAYA | AZARHOUSH R. | Issue Writer Certificate

Keywords

URTICA DIOICA

DIABETES

BLOOD GLUCOSE

KIDNEY

GLOMERULAR

HYPERGLYCEMIA

STREPTOZOTOCIN

Abstract

BACKGROUND AND OBJECTIVE: HYPERGLYCEMIA causes renal morphometric and histological alterations; This study was done to detennine the protective role of URTICA DIOICA on renal morphometric and histological alterations in STREPTOZOTOCIN diabetic rats.METHODS: Thirty adult Wistar rats divided into three groups, Group I normal control group, group II: diabetic group; animal received 80mgkg STZ (streptozotocin) by intraperitoneally and group III: protective group, rats received 100mg/kg daily hydroalcoholic extract of U. dioica for 5 days then DIABETES induced in animals by STZ. In the end of five weeks the animals had been scarified, the KIDNEYs fixed by buffer formaldehyde, processed, sectioned and stained with H&E.FINDINGS: Mean of BLOOD GLUCOSE concentrations in end of fifth weeks were 99.4, 454.7 and 303.6 in control, diabetic and protective groups, respectively (p<0.05), that was lower in protective group than diabetic group. Ration of KIDNEY/body weight in control, DIABETES and protective group were 0.42, 0.51 and 0.48, respectively (p<0.05). GLOMERULAR area in control, DIABETES and protective group were 1335.3, 1441.8 and 1326.4mm2, respectively (p<0.05). GLOMERULAR diameter in diabetic group (162.2mm) was higher than control (156.1) and protective group (153.2). Pathology finding as GLOMERULAR sclerosis was seen in diabetic group but this finding did not observe in control and protective groups.CONCLUSION: This study demonstrated that administration of URTICA DIOICA before STREPTOZOTOCIN-induced DIABETES has protective effects on BLOOD GLUCOSE, renal morphometric and histological alteratios in STREPTOZOTOCIN diabetic rats.

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APA: Copy

GOL ALIPOUR, M.J., MOHAMMAD GHARAAVI, ANEH, GHAFARI, SORAYA, & AZARHOUSH, R.. (2009). PROTECTIVE EFFECT OF URTICA DIOICAON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 10(6 (47)), 43-22. SID. https://sid.ir/paper/559052/en

Vancouver: Copy

GOL ALIPOUR M.J., MOHAMMAD GHARAAVI ANEH, GHAFARI SORAYA, AZARHOUSH R.. PROTECTIVE EFFECT OF URTICA DIOICAON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)[Internet]. 2009;10(6 (47)):43-22. Available from: https://sid.ir/paper/559052/en

IEEE: Copy

M.J. GOL ALIPOUR, ANEH MOHAMMAD GHARAAVI, SORAYA GHAFARI, and R. AZARHOUSH, “PROTECTIVE EFFECT OF URTICA DIOICAON RENAL MORPHOMETRIC AND HISTOLOGIC ALTERATIONS IN STREPTOZOTOCIN DIABETIC RATS,” JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), vol. 10, no. 6 (47), pp. 43–22, 2009, [Online]. Available: https://sid.ir/paper/559052/en

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