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Information Journal Paper

Title

BIOSCREENING OF OXYPEUCEDANIN, A KNOWN FURANOCOUMARIN

Pages

  133-138

Abstract

 Objective(s): As an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. OXYPEUCEDANINe also named as prangolarin is a linear furanocoumarin with an oxygenated prenylated substitution at C-5 of the nucleus. To our knowledge, there are few reports on pharmacological and biological activities of this compound. In the present work, we focused on some bioactive aspects of it.Materials and Methods: In the present work, the compound was purified from PRANGOS ULOPTERA using TLC and its phytotoxic, antibacterial, antifungal, antioxidant and cytotoxic effects were evaluated by Lettuce assay, disc diffusion method, mycelia radial growth, DPPH and MTT assays, respectively.Results: Our results revealed that OXYPEUCEDANIN exhibit considerable PHYTOTOXIC ACTIVITY and might play an allelopathic role for plants. The compound indicated high CYTOTOXIC ACTIVITY with IC50 value of 314 mg/ml. No antipathogenic and antioxidant activity were found for OXYPEUCEDANIN in this study.Conclusion: We conclude that OXYPEUCEDANIN (found in some vegetables) can be considered as an ANTIPROLIFERATIVE AGENT.

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    Cite

    APA: Copy

    RAZAVI, SEYED MAHDI, ZAHRI, S., MOTAMED, ZAHRA, & GHASEMI, GH.. (2010). BIOSCREENING OF OXYPEUCEDANIN, A KNOWN FURANOCOUMARIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 13(3 (46)), 133-138. SID. https://sid.ir/paper/563721/en

    Vancouver: Copy

    RAZAVI SEYED MAHDI, ZAHRI S., MOTAMED ZAHRA, GHASEMI GH.. BIOSCREENING OF OXYPEUCEDANIN, A KNOWN FURANOCOUMARIN. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2010;13(3 (46)):133-138. Available from: https://sid.ir/paper/563721/en

    IEEE: Copy

    SEYED MAHDI RAZAVI, S. ZAHRI, ZAHRA MOTAMED, and GH. GHASEMI, “BIOSCREENING OF OXYPEUCEDANIN, A KNOWN FURANOCOUMARIN,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 13, no. 3 (46), pp. 133–138, 2010, [Online]. Available: https://sid.ir/paper/563721/en

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