SERUM IMMUNOGLOBULIN LEVELS IN SPLENECTOMIZED AND NON- SPLENECTOMIZED PATIENTS WITH MAJOR BETA-THALASSEMIA (SHORT COMMUNICATION)

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KIANI AMIN MOJGAN; DANESHI MOHAMMADMEHDI; AYAZI PARVIZ; MOHAMMADIAN SHIMA; REZAEI NIMA

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Journal: Iranian Journal of Pediatrics Year:2011 | Volume:21 | Issue:1 Page(s): 95-98

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Title

SERUM IMMUNOGLOBULIN LEVELS IN SPLENECTOMIZED AND NON- SPLENECTOMIZED PATIENTS WITH MAJOR BETA-THALASSEMIA (SHORT COMMUNICATION)

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Keywords

HUMORAL IMMUNE SYSTEM

IMMUNOGLOBULINS

MAJOR BETA-THALASSEMIA

SPLENECTOMY

Abstract

Objective: Thalassemia is a common disease in many countries, in which several complications such as infections can occur. Although aberration in the function of the immune system could be a reason for such complication, a little is known about the status of HUMORAL IMMUNE SYSTEM in major beta thalassemia. In this study we measured serum IMMUNOGLOBULINS level in a group of patients with major beta thalassemia.Methods: Ninety nine patients with major beta thalassemia were enrolled in this study divided into two groups of splenctomized and not splenctomized patients. Serum IgG, IgM and IgA levels of these patients were measured and analyzed.Findings: Serum mean levels of IgG and IgM in patients of all ages in both groups were normal. The mean serum IgA level in the group of not splenectomized patients aged less than five years as well as in the splenectomized patients aged more than twenty years was increased. However, it was normal in other age groups.Conclusion: Although this study could not show any defect in the HUMORAL IMMUNE SYSTEM, evaluation of IMMUNOGLOBULINS could be useful to understand the relmarkable high rate of infection in the patients with major beta thalassemia.

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APA: Copy

KIANI AMIN, MOJGAN, DANESHI, MOHAMMADMEHDI, AYAZI, PARVIZ, MOHAMMADIAN, SHIMA, & REZAEI, NIMA. (2011). SERUM IMMUNOGLOBULIN LEVELS IN SPLENECTOMIZED AND NON- SPLENECTOMIZED PATIENTS WITH MAJOR BETA-THALASSEMIA (SHORT COMMUNICATION). IRANIAN JOURNAL OF PEDIATRICS, 21(1), 95-98. SID. https://sid.ir/paper/564320/en

Vancouver: Copy

KIANI AMIN MOJGAN, DANESHI MOHAMMADMEHDI, AYAZI PARVIZ, MOHAMMADIAN SHIMA, REZAEI NIMA. SERUM IMMUNOGLOBULIN LEVELS IN SPLENECTOMIZED AND NON- SPLENECTOMIZED PATIENTS WITH MAJOR BETA-THALASSEMIA (SHORT COMMUNICATION). IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2011;21(1):95-98. Available from: https://sid.ir/paper/564320/en

IEEE: Copy

MOJGAN KIANI AMIN, MOHAMMADMEHDI DANESHI, PARVIZ AYAZI, SHIMA MOHAMMADIAN, and NIMA REZAEI, “SERUM IMMUNOGLOBULIN LEVELS IN SPLENECTOMIZED AND NON- SPLENECTOMIZED PATIENTS WITH MAJOR BETA-THALASSEMIA (SHORT COMMUNICATION),” IRANIAN JOURNAL OF PEDIATRICS, vol. 21, no. 1, pp. 95–98, 2011, [Online]. Available: https://sid.ir/paper/564320/en

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