RELATIONSHIP BETWEEN SERUM LEVELS OF MMP-9 AND LATE OCULAR COMPLICATIONS

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GHAZANFARI T.; YARAEE ROYA; GHASEMI HASAN; MASDARI Z.; VAEZ MAHDAVI M.R.; MOHAMMAD HASAN ZOHEYR; FOROUTAN A.; SOROUSH M.R.; NAGHIZADEH M.M.; FAGHIHZADEH S.

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Journal: Iranian Journal of War and Public Health Year:2009 | Volume:1 | Issue:3 Page(s): 1-16

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Title

RELATIONSHIP BETWEEN SERUM LEVELS OF MMP-9 AND LATE OCULAR COMPLICATIONS

Author(s)

Keywords

MMP9

MUSTARD GAS

CHEMICAL VICTIMS

OCULAR COMPLICATIONS

SARDASHT

Abstract

Background: Sulfur mustard (SM) is a chemical warfare agent which has been used extensively during Iran- Iraq war. One of the major late complications is OCULAR COMPLICATIONS. Matrix metalloproteinases (MMPs) are a group of zinc and calciumdependent endopeptidases which play important roles in the homeostasis of extracellular matrix (ECM) and inflammatory conditions. It has been proved that MMP-9 , as a member of MMPs, is involved in many inflammatory ocular disorders. Aim: The aim of this study was to evaluate the relation between serum MMP-9 and late OCULAR COMPLICATIONS of SM exposure. Methods: In this study, 72 chemical veterans with late OCULAR COMPLICATIONS (case group) & 63 chemical veterans without OCULAR COMPLICATIONS (control group) were selected from SARDASHT via a systematic sampling. Ophthalmologic examinatia of the study group was performed by slit lamp and serum MMP-9 was measured by ELISA sandwich method. Results: The median of serum MMP-9 was 849.3pg/ml in the case group and 787.0pg/ml in the control group. There was no significant statistical difference (p=0.700). There was also no statistical relationship between serum MMP-9 and each involved ocular region.Conclusions: In many studies, It has been proved that MMP-9 expression is increased in tear fluid & culture media of conjunctival & corneal epithelial cells from patients with ocular inflammatory diseases. Therefore, assessment of MMP-9 in mentioned samples of chemical veterans with OCULAR COMPLICATIONS would be valuable.

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APA: Copy

GHAZANFARI, T., YARAEE, ROYA, GHASEMI, HASAN, MASDARI, Z., VAEZ MAHDAVI, M.R., MOHAMMAD HASAN, ZOHEYR, FOROUTAN, A., SOROUSH, M.R., NAGHIZADEH, M.M., & FAGHIHZADEH, S.. (2009). RELATIONSHIP BETWEEN SERUM LEVELS OF MMP-9 AND LATE OCULAR COMPLICATIONS. IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ), 1(3), 1-16. SID. https://sid.ir/paper/564463/en

Vancouver: Copy

GHAZANFARI T., YARAEE ROYA, GHASEMI HASAN, MASDARI Z., VAEZ MAHDAVI M.R., MOHAMMAD HASAN ZOHEYR, FOROUTAN A., SOROUSH M.R., NAGHIZADEH M.M., FAGHIHZADEH S.. RELATIONSHIP BETWEEN SERUM LEVELS OF MMP-9 AND LATE OCULAR COMPLICATIONS. IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ)[Internet]. 2009;1(3):1-16. Available from: https://sid.ir/paper/564463/en

IEEE: Copy

T. GHAZANFARI, ROYA YARAEE, HASAN GHASEMI, Z. MASDARI, M.R. VAEZ MAHDAVI, ZOHEYR MOHAMMAD HASAN, A. FOROUTAN, M.R. SOROUSH, M.M. NAGHIZADEH, and S. FAGHIHZADEH, “RELATIONSHIP BETWEEN SERUM LEVELS OF MMP-9 AND LATE OCULAR COMPLICATIONS,” IRANIAN JOURNAL OF WAR AND PUBLIC HEALTH (TEBE-E-JANBAZ), vol. 1, no. 3, pp. 1–16, 2009, [Online]. Available: https://sid.ir/paper/564463/en

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