EVALUATION 
OF 99MTC-UBIQUICIDIN 29-41 SCINTIGRAPHYIN IN DIFFERENTIATION OF BACTERIAL INFECTION FROM STERILE INFLAMMATIONIN DIABETIC FOOT

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FARD ESFAHANI ARMAGHAN; BEIKI DAVOOD; FALLAHI BABAK; MOHAJERI TEHRANI MOHAMMAD REZA; GHARAIE MOHAMMAD REZA; ROUHIPOUR NAHID; DEHGHANIAN MEHRDAD; SAGHARI MOHSEN; EMAMI ARDEKANI ALIREZA; EFTEKHARI MOHAMMAD

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2010 | Volume:18 | Issue:2 (SERIAL NUMBER 34) Page(s): 20-28

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Title

EVALUATION OF 99MTC-UBIQUICIDIN 29-41 SCINTIGRAPHYIN IN DIFFERENTIATION OF BACTERIAL INFECTION FROM STERILE INFLAMMATIONIN DIABETIC FOOT

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Keywords

SANS-SERIF"> 99M

SANS-SERIF">TC-UBI 29-41

UBIQUICIDIN

DIABETIC FOOT

INFECTION

RADIOLABELED PEPTIDE

Abstract

Introduction: UBIQUICIDIN (UBI) 29-41 is a synthetic antimicrobial peptide that binds with the microbial cell membrane at the location of INFECTION. This study was conducted to evaluate its probable efficacy as an INFECTION-imaging agent with potential to differentiate bacterial INFECTION from sterile inflammation in humans.Methods: Fifteen DIABETIC FOOT patients (10 males and 5 females) with suspected bacterial INFECTION, prior to starting antibiotic treatment, were selected for this study. First a routine three phase bone scan and later a 99mTc-UBI scan was performed for all the patients. 555-740 MBq of 99mTc-UBI was injected intravenously. A 10 minute dynamic study was followed by spot views of the suspected region of INFECTION and corresponding normal areas (liver and kidneys) at 60 and 120 min. Whole-body anterior and posterior images were also acquired. To interpret the studies as positive or negative, visual score (0 -3) was used, with scores of 0 (minimal or no uptake; equivalent to soft tissue) and 1 (mild; less uptake than in liver) being considered negative and scores of 2 (moderate; uptake equal to or greater than that in liver) and 3 (intense uptake equal to or greater than that in kidneys) being considered positive.Results: Of 15 studies performed with 99mTc-UBI, all had positive bacterial cultures. The result of bone scan was positive for osteomyelitis in 12 patients (80%). 99mTc-UBI Scintigraphy was positive in 6 patients, but negative in nine. The sensitivity of 99mTc-UBI for detection of INFECTION was therefore 40%. From 12 patients who had positive bone scans, only 6 had a positive 99mTc-UBI (50%) indicating the sensitivity of 50% for 99mTc-UBI in osteomyelitis cases. 99mTc-UBI was not positive in any patient who had evidence of soft tissue INFECTION in the bone scan.Conclusion: Although 99mTc-UBI 29-41 was well tolerated by all the patients without any side effects, considering low sensitivity of this agent, this radiopharmaceutical is not of great value for DIABETIC FOOT INFECTION diagnosis.

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APA: Copy

FARD ESFAHANI, ARMAGHAN, BEIKI, DAVOOD, FALLAHI, BABAK, MOHAJERI TEHRANI, MOHAMMAD REZA, GHARAIE, MOHAMMAD REZA, ROUHIPOUR, NAHID, DEHGHANIAN, MEHRDAD, SAGHARI, MOHSEN, EMAMI ARDEKANI, ALIREZA, & EFTEKHARI, MOHAMMAD. (2010). EVALUATION OF ^99MTC-UBIQUICIDIN 29-41 SCINTIGRAPHYIN IN DIFFERENTIATION OF BACTERIAL INFECTION FROM STERILE INFLAMMATIONIN DIABETIC FOOT. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(2 (SERIAL NUMBER 34)), 20-28. SID. https://sid.ir/paper/564465/en

Vancouver: Copy

FARD ESFAHANI ARMAGHAN, BEIKI DAVOOD, FALLAHI BABAK, MOHAJERI TEHRANI MOHAMMAD REZA, GHARAIE MOHAMMAD REZA, ROUHIPOUR NAHID, DEHGHANIAN MEHRDAD, SAGHARI MOHSEN, EMAMI ARDEKANI ALIREZA, EFTEKHARI MOHAMMAD. EVALUATION OF ^99MTC-UBIQUICIDIN 29-41 SCINTIGRAPHYIN IN DIFFERENTIATION OF BACTERIAL INFECTION FROM STERILE INFLAMMATIONIN DIABETIC FOOT. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(2 (SERIAL NUMBER 34)):20-28. Available from: https://sid.ir/paper/564465/en

IEEE: Copy

ARMAGHAN FARD ESFAHANI, DAVOOD BEIKI, BABAK FALLAHI, MOHAMMAD REZA MOHAJERI TEHRANI, MOHAMMAD REZA GHARAIE, NAHID ROUHIPOUR, MEHRDAD DEHGHANIAN, MOHSEN SAGHARI, ALIREZA EMAMI ARDEKANI, and MOHAMMAD EFTEKHARI, “EVALUATION OF ^99MTC-UBIQUICIDIN 29-41 SCINTIGRAPHYIN IN DIFFERENTIATION OF BACTERIAL INFECTION FROM STERILE INFLAMMATIONIN DIABETIC FOOT,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. 2 (SERIAL NUMBER 34), pp. 20–28, 2010, [Online]. Available: https://sid.ir/paper/564465/en

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