EFFECT OF COMBINED 2- METHOXYESTRADIOL AND METHOXYAMINE ON SENSITIVITY OF IUDR YIELDING COBALT 60 GAMMA IN SPHEROID MODEL CULTURED GLIOBLASTOMA CELLS BY COLONY ASSAY MEASUREMENT METHOD

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BABALOUEY SOMAYEH; NESHASTEHRIZ ALI; KHOEI SAMIDEH; AZARIAN MARYAM

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Journal: Lasers in Medicine Year:2009 | Volume:6 | Issue:3 (33) Page(s): 29-34

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Title

EFFECT OF COMBINED 2- METHOXYESTRADIOL AND METHOXYAMINE ON SENSITIVITY OF IUDR YIELDING COBALT 60 GAMMA IN SPHEROID MODEL CULTURED GLIOBLASTOMA CELLS BY COLONY ASSAY MEASUREMENT METHOD

Author(s)

BABALOUEY SOMAYEH | NESHASTEHRIZ ALI | KHOEI SAMIDEH | AZARIAN MARYAM | Issue Writer Certificate

Keywords

HYPOXIA INDUCTION FACTOR (HIF-IA)

IUDR

2- METHOXYESTRADIOL

METHOXYAMINE

SPHEROID

Abstract

Introduction: Glioblastoma is one of the most common and a dangerous cancer of central nervous system.Targeted radiotherapy is an effective method in its treatment. IUDR is -a thymine analog- known as a radiation sensitizer in cancer therapy. It has been reported that METHOXYAMINE increase base cutting healing blocking in DNA damages levels in cells derived from human Glioblastoma, while the degree of DNA fractures in larger SPHEROIDs were decreased, this matter was affected by increasing in IUDR uptake by harvested cells in G0 phase is. HIF-la is a transcription factor for endothelial cells stop cell cycle phase G 0 / G 1. Recently has been recognized that activity by HIF-1a can be cause 2 - Methoxyestradiol inhibited, this issue that is leads to inhibition of cell cycle stopping.Material and Methods: In this studywe have investigatedcombinedingeffect 2 - Methoxyestradiolon radio sensitivity consideration of IUDR in SPHEROID cell culture model Glioblastoma. U87MG cells cytotoxic damages were tested by colony assay and the colonogenic ability of cells were evaluated and compared in 350 microns spheroieds.Result: Our results shown that the damage resulted by ionizing radiation before yielding in IUDR treated with estradiol and METHOXYAMINE much more (001 / 0³p) of the use each of these factors alone are.Conclusion: These results were indicated the important role of methoxyestradiol in related by IUDR in cancertherapy.

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APA: Copy

BABALOUEY, SOMAYEH, NESHASTEHRIZ, ALI, KHOEI, SAMIDEH, & AZARIAN, MARYAM. (2009). EFFECT OF COMBINED 2- METHOXYESTRADIOL AND METHOXYAMINE ON SENSITIVITY OF IUDR YIELDING COBALT 60 GAMMA IN SPHEROID MODEL CULTURED GLIOBLASTOMA CELLS BY COLONY ASSAY MEASUREMENT METHOD. LASER IN MEDICINE, 6(3 (33)), 29-34. SID. https://sid.ir/paper/564589/en

Vancouver: Copy

BABALOUEY SOMAYEH, NESHASTEHRIZ ALI, KHOEI SAMIDEH, AZARIAN MARYAM. EFFECT OF COMBINED 2- METHOXYESTRADIOL AND METHOXYAMINE ON SENSITIVITY OF IUDR YIELDING COBALT 60 GAMMA IN SPHEROID MODEL CULTURED GLIOBLASTOMA CELLS BY COLONY ASSAY MEASUREMENT METHOD. LASER IN MEDICINE[Internet]. 2009;6(3 (33)):29-34. Available from: https://sid.ir/paper/564589/en

IEEE: Copy

SOMAYEH BABALOUEY, ALI NESHASTEHRIZ, SAMIDEH KHOEI, and MARYAM AZARIAN, “EFFECT OF COMBINED 2- METHOXYESTRADIOL AND METHOXYAMINE ON SENSITIVITY OF IUDR YIELDING COBALT 60 GAMMA IN SPHEROID MODEL CULTURED GLIOBLASTOMA CELLS BY COLONY ASSAY MEASUREMENT METHOD,” LASER IN MEDICINE, vol. 6, no. 3 (33), pp. 29–34, 2009, [Online]. Available: https://sid.ir/paper/564589/en

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