THE EFFECTS OF BARE METAL VERSUS DRUG-ELUTING STENT IMPLANTATION ON CIRCULATING ENDOTHELIAL CELLS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION

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HASHEMI JAZI SEYED MOHAMMAD; SHAFIEI SAEED; ZARKESH ESFAHANI SEYED HAMID; MALEKI VAREKI SAMAN; HAGHJOOY JAVANMARD SHAGHAYEGH

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:5 Page(s): 605-610

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Title

THE EFFECTS OF BARE METAL VERSUS DRUG-ELUTING STENT IMPLANTATION ON CIRCULATING ENDOTHELIAL CELLS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION

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Keywords

ANGIOPLASTY

BALLOON

CORONARY

DRUG-ELUTING STENTS

ENDOTHELIAL CELLS

Abstract

BACKGROUND: The purpose of this study was to compare the effects of bare metal stents (BMS) and DRUG-ELUTING STENTS (DES) implantation on circulating ENDOTHELIAL CELLS (CECs) which have been proposed as cellular markers of endothelial dysfunction following percutaneous CORONARY intervention (PCI). Recently, it has been established that DES further reduce restenosis and revascularization rate compared to bare metal stents in elective procedures. However, its benefits are compromised by the stent-related thrombosis events.METHODS: 22 patients who were candidate of PCI were included in this study. The patients underwent DES implantation (n=11) or BMS implantation (n=11). In all patients the numbers of CECs were determined before and a week after stent implantation using flow cytometry and the obtained data were compared within and between groups by paired and unpaired Student's t-test, respectively. CECs were defined as cells negative for CD45 (FITC) and highly double positive for CD146 (PE) and CD34 (PE-Cy5) expression.RESULTS: There were no significant differences in the baseline levels of CECs between two groups (p=0.96). Stent implantation led to a significant increase in CECs compared with the preprocedural levels in the BMS group (p=0.005) whereas there was a significant decrease in CEC numbers in DES group (p<0.001). One week after stent implantation CECs count in BMS group was significantly higher compared to DES group (p<0.001).CONCLUSIONS: The results indicate that patients undergoing DES implantation were subjected to less endothelial injury than patients receiving BMS as indicated by CEC enumeration.

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APA: Copy

HASHEMI JAZI, SEYED MOHAMMAD, SHAFIEI, SAEED, ZARKESH ESFAHANI, SEYED HAMID, MALEKI VAREKI, SAMAN, & HAGHJOOY JAVANMARD, SHAGHAYEGH. (2011). THE EFFECTS OF BARE METAL VERSUS DRUG-ELUTING STENT IMPLANTATION ON CIRCULATING ENDOTHELIAL CELLS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(5), 605-610. SID. https://sid.ir/paper/564673/en

Vancouver: Copy

HASHEMI JAZI SEYED MOHAMMAD, SHAFIEI SAEED, ZARKESH ESFAHANI SEYED HAMID, MALEKI VAREKI SAMAN, HAGHJOOY JAVANMARD SHAGHAYEGH. THE EFFECTS OF BARE METAL VERSUS DRUG-ELUTING STENT IMPLANTATION ON CIRCULATING ENDOTHELIAL CELLS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(5):605-610. Available from: https://sid.ir/paper/564673/en

IEEE: Copy

SEYED MOHAMMAD HASHEMI JAZI, SAEED SHAFIEI, SEYED HAMID ZARKESH ESFAHANI, SAMAN MALEKI VAREKI, and SHAGHAYEGH HAGHJOOY JAVANMARD, “THE EFFECTS OF BARE METAL VERSUS DRUG-ELUTING STENT IMPLANTATION ON CIRCULATING ENDOTHELIAL CELLS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 5, pp. 605–610, 2011, [Online]. Available: https://sid.ir/paper/564673/en

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