ASSESSMENT OF PD-1 GENE VARIATION IN PATIENTS WITH MULTIPLE SCLEROSIS

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AHMADI SHADMEHRI ASHRAF; NICKNAM MOHAMMAD HOSEIN; SHOKRGOZAR MOHAMMAD ALI; MAHMOUDI MEHDI; SARIAL SHILA; AHMADI SHADMEHRI AZAM; MORADI BATOOL; FARHADI ELHAM; AMIRZARGAR ALI AKBAR

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Journal: Tehran University Medical Journal Year:2010 | Volume:68 | Issue:2 Page(s): 87-92

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Title

ASSESSMENT OF PD-1 GENE VARIATION IN PATIENTS WITH MULTIPLE SCLEROSIS

Author(s)

Keywords

MULTIPLE SCLEROSIS

PD-1

PDCD1

POLYMORPHISM

Abstract

Background: MULTIPLE SCLEROSIS (MS) is a chronic inflammatory demyelinating disease of the central nervous system with presumed autoimmune origin. T cells are considered to play a pivotal role in orchestrating the self-reactive immune responses in MULTIPLE SCLEROSIS (MS). This study was performed to investigate the role of POLYMORPHISMs of the programmed cell death 1 (PD-1) gene on susceptibility to ankylosing spondylitis. This gene codes an immunoreceptor named PD-1, which has a cytoplasmic domain containing two tyrosine residues located within immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM), suggesting that PD-1 is predominantly inhibitory which responsible for the negative regulation in T cell activation and peripheral tolerance. We investigated whether PD-1 gene POLYMORPHISM is a genetic modifier for risk and progression of MS.Methods: Blood samples from 150 Iranian Relapsing-Remitting MS patients (mean age, 34.98 years) and 202 healthy controls (mean age, 30 years) were enrolled in this study. The PD-1.3 (7146 G/A Intron 4) and PD-1.9 (7625 C/T Exon 5) POLYMORPHISMs were detected by Polymerase Chain Reaction and Restriction Enzyme digestion or Restriction Fragment Length POLYMORPHISM (PCR-RFLP).Results: No significant association of the mutated alleles with the disease were detected. Because of the ethnic group genetic variation, our data is not like some of Asian population such as Korea and China.Conclusions: Our data suggest that PD-1 POLYMORPHISMs are not act as genetic modifiers of the progression of MS, possibly these POLYMORPHISMs don' t induce a partial defect in PD-1 mediated inhibition of T-cell activation.

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APA: Copy

AHMADI SHADMEHRI, ASHRAF, NICKNAM, MOHAMMAD HOSEIN, SHOKRGOZAR, MOHAMMAD ALI, MAHMOUDI, MEHDI, SARIAL, SHILA, AHMADI SHADMEHRI, AZAM, MORADI, BATOOL, FARHADI, ELHAM, & AMIRZARGAR, ALI AKBAR. (2010). ASSESSMENT OF PD-1 GENE VARIATION IN PATIENTS WITH MULTIPLE SCLEROSIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(2), 87-92. SID. https://sid.ir/paper/565980/en

Vancouver: Copy

AHMADI SHADMEHRI ASHRAF, NICKNAM MOHAMMAD HOSEIN, SHOKRGOZAR MOHAMMAD ALI, MAHMOUDI MEHDI, SARIAL SHILA, AHMADI SHADMEHRI AZAM, MORADI BATOOL, FARHADI ELHAM, AMIRZARGAR ALI AKBAR. ASSESSMENT OF PD-1 GENE VARIATION IN PATIENTS WITH MULTIPLE SCLEROSIS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(2):87-92. Available from: https://sid.ir/paper/565980/en

IEEE: Copy

ASHRAF AHMADI SHADMEHRI, MOHAMMAD HOSEIN NICKNAM, MOHAMMAD ALI SHOKRGOZAR, MEHDI MAHMOUDI, SHILA SARIAL, AZAM AHMADI SHADMEHRI, BATOOL MORADI, ELHAM FARHADI, and ALI AKBAR AMIRZARGAR, “ASSESSMENT OF PD-1 GENE VARIATION IN PATIENTS WITH MULTIPLE SCLEROSIS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 2, pp. 87–92, 2010, [Online]. Available: https://sid.ir/paper/565980/en

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