PROBING SINGLE HEMATOPOIETIC STEM CELL (HSC) FATE DECISION-MAKING IN ARTIFICIAL NICHES (INVITED SPEAKERS)

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LUTOLF M.P.

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Journal Paper

Paper Information

Journal: CELL JOURNAL (YAKHTEH) Year:2011 | Volume:13 | Issue:SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY) Page(s): 9-9

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Title

PROBING SINGLE HEMATOPOIETIC STEM CELL (HSC) FATE DECISION-MAKING IN ARTIFICIAL NICHES (INVITED SPEAKERS)

Author(s)

LUTOLF M.P.

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Abstract

The remarkable ability of stem cells to renew themselves and to give rise to specialized cell types has raised huge hope for their clinical application. However, our limited understanding of the mechanisms that regulate stem cells poses a substantial hurdle for their clinical use: Since we know relatively little about how stem cells function, it is not surprising that we also struggle in growing them in a cell culture dish; most likely an important requirement for stem cell-based therapies.I believe that one cause of this problem is the inadequacy of tools that we have available to study stem cells at the single cell level. That is to say, even after careful prospective isolation based on immunophenotype, individual stem cells of a well-defined population behave highly heterogeneous in culture: some cells divide rapidly and others more slowly; some self-renew while others begin to differentiate; some can give rise to more lineages than others, etc. Because of this inherent variability, population-based studies of stem cells are essentially ‘black boxes’ and often unable to accurately address key biological questions, such as defining the discrete development steps from a single stem cell to a complex population of specialized cells (lineage development), or elucidating the mechanisms that regulate symmetric versus asymmetric divisions of stem cells.In this talk I will highlight recent efforts in my lab to address this important problem by developing and applying microfluidic technology to sequentially capture single HSC after multiple divisions to assess their fate, and in particular the symmetry of division, by multigene single cell qRT-PCR.

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APA: Copy

LUTOLF, M.P.. (2011). PROBING SINGLE HEMATOPOIETIC STEM CELL (HSC) FATE DECISION-MAKING IN ARTIFICIAL NICHES (INVITED SPEAKERS). CELL JOURNAL (YAKHTEH), 13(SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY)), 9-9. SID. https://sid.ir/paper/565998/en

Vancouver: Copy

LUTOLF M.P.. PROBING SINGLE HEMATOPOIETIC STEM CELL (HSC) FATE DECISION-MAKING IN ARTIFICIAL NICHES (INVITED SPEAKERS). CELL JOURNAL (YAKHTEH)[Internet]. 2011;13(SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY)):9-9. Available from: https://sid.ir/paper/565998/en

IEEE: Copy

M.P. LUTOLF, “PROBING SINGLE HEMATOPOIETIC STEM CELL (HSC) FATE DECISION-MAKING IN ARTIFICIAL NICHES (INVITED SPEAKERS),” CELL JOURNAL (YAKHTEH), vol. 13, no. SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY), pp. 9–9, 2011, [Online]. Available: https://sid.ir/paper/565998/en

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