FREQUENCY OF SENSORY NEURAL HEARING LOSS IN MAJOR BETA-THALASSEMIAS IN SOUTHERN IRAN

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FARAMARZI A.A.H.; KARIMI MEHRAN; HEYDARI SEYED TAGHI; SHISHEGAR M.; KAVIANI M.

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Journal Paper

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Journal: Iranian Journal of Pediatrics Year:2010 | Volume:20 | Issue:3 Page(s): 308-312

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Title

FREQUENCY OF SENSORY NEURAL HEARING LOSS IN MAJOR BETA-THALASSEMIAS IN SOUTHERN IRAN

Author(s)

Keywords

THALASSEMIA

SENSORINEURAL HEARING LOSS

BLOOD TRANSFUSION

DEFEROXAMINE

FERRITIN

Abstract

Objective: The THALASSEMIAs are among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean region. The aim of this study was to determined frequency of sensory-neural hearing loss in major b- THALASSEMIAs transfusion dependent patients in south of Iran.Methods: A cross sectional study on 308 cases of major beta-THALASSEMIA patients referring to THALASSEMIA Center of Shiraz University of Medical Sciences between 2006-2007 years. The diagnosis of b- THALASSEMIA major was based on clinical history, complete blood count and hemoglobine electrophoresis. Clinical data such as serum FERRITIN level, DEFEROXAMINE (DFO) dose, mean daily doses of DFO (mg/kg) and audiometric variables was recorded. Findings: Out of 308 cases, 283 (96.5%) had normal hearing and 10 (3.5%) SENSORINEURAL HEARING LOSS. There was no statically significant difference between two groups regarding mean age, weight, age at the first BLOOD TRANSFUSION, age at the first DFO infusion.Conclusion: We found the lowest incidence of SENSORINEURAL HEARING LOSS in a large population of patients suffered from major THALASSEMIA who received DFO. We show that DFO is not ototoxic at a low dose. When considering all related literature, as a whole there has been much critical misrepresentation about DFO ototoxicity.

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APA: Copy

FARAMARZI, A.A.H., KARIMI, MEHRAN, HEYDARI, SEYED TAGHI, SHISHEGAR, M., & KAVIANI, M.. (2010). FREQUENCY OF SENSORY NEURAL HEARING LOSS IN MAJOR BETA-THALASSEMIAS IN SOUTHERN IRAN. IRANIAN JOURNAL OF PEDIATRICS, 20(3), 308-312. SID. https://sid.ir/paper/566587/en

Vancouver: Copy

FARAMARZI A.A.H., KARIMI MEHRAN, HEYDARI SEYED TAGHI, SHISHEGAR M., KAVIANI M.. FREQUENCY OF SENSORY NEURAL HEARING LOSS IN MAJOR BETA-THALASSEMIAS IN SOUTHERN IRAN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2010;20(3):308-312. Available from: https://sid.ir/paper/566587/en

IEEE: Copy

A.A.H. FARAMARZI, MEHRAN KARIMI, SEYED TAGHI HEYDARI, M. SHISHEGAR, and M. KAVIANI, “FREQUENCY OF SENSORY NEURAL HEARING LOSS IN MAJOR BETA-THALASSEMIAS IN SOUTHERN IRAN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 20, no. 3, pp. 308–312, 2010, [Online]. Available: https://sid.ir/paper/566587/en

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