TESTOSTERONE ENANTHATE SUPPRESSES APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN

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GHASEMI F.M.; FAGHANI M.; NASIRI EBRAHIM; BAHADORI M.H.; SOLTANI B.

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Paper Information

Journal: Cell Journal (Yakhteh) Year:2009 | Volume:11 | Issue:SUPPL. 1 Page(s): 42-43

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Title

TESTOSTERONE ENANTHATE SUPPRESSES APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN

Author(s)

GHASEMI F.M. | FAGHANI M. | NASIRI EBRAHIM | BAHADORI M.H. | SOLTANI B.

Keywords

CHEMOTHERAPY

TESTOSTERONE ENANTHATE

GERM CELL APOPTOSIS

TESTIS

Abstract

Objective: This study was performed to investigate the suppressive effect of testosterone enantate on male germ cells apoptosis induced by busulfan in rats.Materials and Methods: Sprague- Dawley rats were divided into 4 groups: 1. a control group given cotton seed oil, 2. a group given two doses of busulfan 10 mg/kg intraperitoneally, 21 days apart, 3. a group given two doses of testosterone enantate 8mg/kg subcutaneously, 21 days apart, 4. a group given both testosterone anantate and busulfan. Evaluations were made by determining johnsen’s score and apoptosis were assayed by terminal- deoxynucleotidyl- transferase-mediated dutp nick end labeling (TUNEL).Results: Recovery status and johnsen’s score in group 4(busulfan + testosterone) were significantly higher than group 2(busulfan) 7.4±0.20 VS 4.1±0.22, TUNEL positive cells were significantly more numerous in busulfan treated group than control. While testosterone significantly attenuated morphological changes and GERM CELL APOPTOSIS in TESTIS damaged by busulfan.Conclusion: These results suggest testosterone enantate have chemoprotective effect on male germ cells against busulfan-induced toxicity partly by decreasing of apoptosis.

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APA: Copy

GHASEMI, F.M., FAGHANI, M., NASIRI, EBRAHIM, BAHADORI, M.H., & SOLTANI, B.. (2009). TESTOSTERONE ENANTHATE SUPPRESSES APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN. CELL JOURNAL (YAKHTEH), 11(SUPPL. 1), 42-43. SID. https://sid.ir/paper/567316/en

Vancouver: Copy

GHASEMI F.M., FAGHANI M., NASIRI EBRAHIM, BAHADORI M.H., SOLTANI B.. TESTOSTERONE ENANTHATE SUPPRESSES APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN. CELL JOURNAL (YAKHTEH)[Internet]. 2009;11(SUPPL. 1):42-43. Available from: https://sid.ir/paper/567316/en

IEEE: Copy

F.M. GHASEMI, M. FAGHANI, EBRAHIM NASIRI, M.H. BAHADORI, and B. SOLTANI, “TESTOSTERONE ENANTHATE SUPPRESSES APOPTOSIS IN MALE GERM CELLS INDUCED BY BUSULFAN,” CELL JOURNAL (YAKHTEH), vol. 11, no. SUPPL. 1, pp. 42–43, 2009, [Online]. Available: https://sid.ir/paper/567316/en

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