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Information Journal Paper

Title

EVALUATION OF BCL-2 FAMILY GENE EXPRESSION IN HIPPOCAMPUS OF 3, 4-METHYLENEDIOXYMETHAMPHETAMINE TREATED RATS

Pages

  275-280

Keywords

3 
4-METHYLENDIOXYMETHAMPHETAMINE (MDMA) 
BAX 

Abstract

 Objective: 3, 4-methylenedioxymethamphetamine (MDMA) is an illicit, recreational drug that causes cellular death and neurotoxicity. This study evaluates the effects of different doses of MDMA on the expression of APOPTOSIS–related proteins and genes in the hippocampus of adult rats.Materials and Methods: In this expremental study, a total of 20 male Sprague Dawley rats (200-250 g) were treated with MDMA (0, 5, 10, 20 mg/kg i.p. twice daily) for 7 days.Seven days after the last administration of MDMA, the rats were killed. BAX and BCL-2 genes in addition to protein expressions were detected by western blot and reverse transcriptionpolymerase chain reaction (RT-PCR). Results were analyzed using one-way ANOVA and p£0.05 was considered statistically significant.Results: Our results showed that MDMA caused dose dependent up-regulation of BAX and down-regulation of BCL-2 in the hippocampus. There was a significant alteration in BCL-2 and BAX genes density.Conclusion: Changes in APOPTOSIS-related proteins and respective genes relating to BAX and BCL-2 might be involved in the molecular mechanism of MDMA-induced APOPTOSIS.

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    APA: Copy

    SOLEIMANI ASL, SARA, FARHADI, MOHAMMAD HASSAN, MOOSAVIZADEH, KAZEM, SAMADI KUCHAK SARAEI, ALI, SOLEYMANI, MANSOUREH, JAMEI, SEID BEHNAMELDIN, JOGHATAEI, MOHAMMAD TAGHI, SAMZADEH KERMANI, ALIREZA, HASHEMI NASL, HAMED, & MEHDIZADEH, MEHDI. (2012). EVALUATION OF BCL-2 FAMILY GENE EXPRESSION IN HIPPOCAMPUS OF 3, 4-METHYLENEDIOXYMETHAMPHETAMINE TREATED RATS. CELL JOURNAL (YAKHTEH), 13(4 (52)), 275-280. SID. https://sid.ir/paper/568806/en

    Vancouver: Copy

    SOLEIMANI ASL SARA, FARHADI MOHAMMAD HASSAN, MOOSAVIZADEH KAZEM, SAMADI KUCHAK SARAEI ALI, SOLEYMANI MANSOUREH, JAMEI SEID BEHNAMELDIN, JOGHATAEI MOHAMMAD TAGHI, SAMZADEH KERMANI ALIREZA, HASHEMI NASL HAMED, MEHDIZADEH MEHDI. EVALUATION OF BCL-2 FAMILY GENE EXPRESSION IN HIPPOCAMPUS OF 3, 4-METHYLENEDIOXYMETHAMPHETAMINE TREATED RATS. CELL JOURNAL (YAKHTEH)[Internet]. 2012;13(4 (52)):275-280. Available from: https://sid.ir/paper/568806/en

    IEEE: Copy

    SARA SOLEIMANI ASL, MOHAMMAD HASSAN FARHADI, KAZEM MOOSAVIZADEH, ALI SAMADI KUCHAK SARAEI, MANSOUREH SOLEYMANI, SEID BEHNAMELDIN JAMEI, MOHAMMAD TAGHI JOGHATAEI, ALIREZA SAMZADEH KERMANI, HAMED HASHEMI NASL, and MEHDI MEHDIZADEH, “EVALUATION OF BCL-2 FAMILY GENE EXPRESSION IN HIPPOCAMPUS OF 3, 4-METHYLENEDIOXYMETHAMPHETAMINE TREATED RATS,” CELL JOURNAL (YAKHTEH), vol. 13, no. 4 (52), pp. 275–280, 2012, [Online]. Available: https://sid.ir/paper/568806/en

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