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Information Journal Paper

Title

PRODUCTION, QUALITY CONTROL AND IMAGING OF 64CU-ATSM IN HEALTHY RABBITS FOR CLINICAL APPLICATIONS

Pages

  29-37

Keywords

QUALITY 
SANS-SERIF"> CONTROL 
[64CU] ATSM 

Abstract

 Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy RABBITS is reported.Methods: Copper-64 produced via the 68Zn (p,an)64Cu nuclear reaction (30 MeV protons at 180 µA) was used for the preparation of [64Cu]diacetyl-bis(N4-methylthiosemicarbazone)([64Cu]ATSM). Followed by quality control and administration to healthy rats as well as healthy RABBITS for BIODISTRIBUTION and imaging studies respectively.Results: 64Cu2+ (500 mCi, separation yield> 95%, radionuclide purity>96%) was used for [64Cu] ATSM production (radiochemical purity>99%, specific activity of 300 Ci/mmol) followed by administration to healthy RABBITS and COINCIDENCE IMAGING demonstrating uptake in liver, kidney and bowel as shown by other reports in various rodents and human.Conclusion: [64Cu] ATSM radiopharmaceutical is produced and now available in large quantities for research and/or clinical trials in the country.

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    APA: Copy

    FAZAELI, YOUSEF, JALILIAN, AMIR REZA, KAMALI DEHGHAN, MOHSEN, BOLOURINOVIN, FATEMEH, MORADKHANI, SEDIGHEH, ASLANI, GHOLAMREZA, RAHIMINEJAD, ALI, & GHANNADI MARAGHEH, MOHAMMAD. (2010). PRODUCTION, QUALITY CONTROL AND IMAGING OF 64CU-ATSM IN HEALTHY RABBITS FOR CLINICAL APPLICATIONS. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(2 (SERIAL NUMBER 34)), 29-37. SID. https://sid.ir/paper/568834/en

    Vancouver: Copy

    FAZAELI YOUSEF, JALILIAN AMIR REZA, KAMALI DEHGHAN MOHSEN, BOLOURINOVIN FATEMEH, MORADKHANI SEDIGHEH, ASLANI GHOLAMREZA, RAHIMINEJAD ALI, GHANNADI MARAGHEH MOHAMMAD. PRODUCTION, QUALITY CONTROL AND IMAGING OF 64CU-ATSM IN HEALTHY RABBITS FOR CLINICAL APPLICATIONS. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(2 (SERIAL NUMBER 34)):29-37. Available from: https://sid.ir/paper/568834/en

    IEEE: Copy

    YOUSEF FAZAELI, AMIR REZA JALILIAN, MOHSEN KAMALI DEHGHAN, FATEMEH BOLOURINOVIN, SEDIGHEH MORADKHANI, GHOLAMREZA ASLANI, ALI RAHIMINEJAD, and MOHAMMAD GHANNADI MARAGHEH, “PRODUCTION, QUALITY CONTROL AND IMAGING OF 64CU-ATSM IN HEALTHY RABBITS FOR CLINICAL APPLICATIONS,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. 2 (SERIAL NUMBER 34), pp. 29–37, 2010, [Online]. Available: https://sid.ir/paper/568834/en

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