EXPRESSION PATTERN OF REST IN HESCS AND HIPSCS UNDERGOING NEURAL DIFFERENTIATION (POSTER PRESENTATION)

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ANSARI H.; NEMATI SH.; KIANI S.; BAHARVEND H.; SHAHHOSSEINI M.

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Paper Information

Journal: Cell Journal (Yakhteh) Year:2011 | Volume:13 | Issue:SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY) Page(s): 24-24

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Title

EXPRESSION PATTERN OF REST IN HESCS AND HIPSCS UNDERGOING NEURAL DIFFERENTIATION (POSTER PRESENTATION)

Author(s)

ANSARI H. | NEMATI SH. | KIANI S. | BAHARVEND H. | SHAHHOSSEINI M.

Keywords

REST

HESC

HIPSC

NSC

NEURAL CELLS

Abstract

Objective: The neuronal repressor REST (RE1-silencing transcription factor) is expressed at high levels in embryonic stem cells (ESC) with a critical role in self-renewal and pluripotency signaling network of these cells. REST is an essential element for brain development and also neuronal differentiation of ESC in vitro. Although REST is a well-known regulatory element in embryonic stem cells, but according to our knowledge, it has not been evaluated in induced pluripotent stem cell (iPSC) till now.Materials and Methods: The quantitative expression of REST in each step was evaluated by real-time PCR and the presence of REST was showed by immunofluorescent assay.Results: Q-PCR analysis showed that the expression level of REST decreased significantly during differentiation of HIPSCs to neural precursor cells, and remained stable until neuronal differentiation. immunofluorescent data revealed the both nuclear as cytoplasmic presence of REST in HIPSCs as well as NSCs, while in the maturated neurons it was only detectable in the cytoplasm.Conclusion: Our findings show a distinct expression pattern for REST during HESCs and HIPSCs neural differentiation. This study opens a new window for further experiments in this field to receive efficient differentiation of neuronal cells.

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APA: Copy

ANSARI, H., NEMATI, SH., KIANI, S., BAHARVEND, H., & SHAHHOSSEINI, M.. (2011). EXPRESSION PATTERN OF REST IN HESCS AND HIPSCS UNDERGOING NEURAL DIFFERENTIATION (POSTER PRESENTATION). CELL JOURNAL (YAKHTEH), 13(SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY)), 24-24. SID. https://sid.ir/paper/569600/en

Vancouver: Copy

ANSARI H., NEMATI SH., KIANI S., BAHARVEND H., SHAHHOSSEINI M.. EXPRESSION PATTERN OF REST IN HESCS AND HIPSCS UNDERGOING NEURAL DIFFERENTIATION (POSTER PRESENTATION). CELL JOURNAL (YAKHTEH)[Internet]. 2011;13(SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY)):24-24. Available from: https://sid.ir/paper/569600/en

IEEE: Copy

H. ANSARI, SH. NEMATI, S. KIANI, H. BAHARVEND, and M. SHAHHOSSEINI, “EXPRESSION PATTERN OF REST IN HESCS AND HIPSCS UNDERGOING NEURAL DIFFERENTIATION (POSTER PRESENTATION),” CELL JOURNAL (YAKHTEH), vol. 13, no. SUPPLEMENT 3 (7TH CONGRESS ON STEM CELL BIOLOGY AND TECHNOLOGY), pp. 24–24, 2011, [Online]. Available: https://sid.ir/paper/569600/en

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