ROLE OF CALPAIN IN APOPTOSIS

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MOMENI HAMID REZA

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2011 | Volume:13 | Issue:2 (50) Page(s): 65-72

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Information Journal Paper

Title

ROLE OF CALPAIN IN APOPTOSIS

Author(s)

MOMENI HAMID REZA | Issue Writer Certificate

Keywords

APOPTOSIS

CALPAIN

CALPAIN SUBSTRATES

Abstract

APOPTOSIS, a form of programmed cell death that occurs under physiological as well as pathological conditions, is characterized by morphological and biochemical features. While the importance of caspases in APOPTOSIS is established, several noncaspase proteases (Ca 2+-dependent proteases) such as CALPAIN may play a role in the execution of APOPTOSIS. The CALPAIN family consists of two major isoforms, CALPAIN I and CALPAIN II which require mM and mM Ca 2+ concentrations to initiate their activity. An increase in intracellular Ca 2+ level is thought to trigger a cascade of biochemical processes including CALPAIN activation.Once activated, CALPAINs degrade membrane, cytoplasmic and nuclear substrates, leading to the breakdown of cellular architecture and finally APOPTOSIS.The activation of CALPAIN has been implicated in neuronal APOPTOSIS following spinal cord injuries and neurodegenerative diseases. This review focuses on CALPAIN with an emphasis on its key role in the proteolysis of cellular protein substrates following APOPTOSIS.

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APA: Copy

MOMENI, HAMID REZA. (2011). ROLE OF CALPAIN IN APOPTOSIS. CELL JOURNAL (YAKHTEH), 13(2 (50)), 65-72. SID. https://sid.ir/paper/569664/en

Vancouver: Copy

MOMENI HAMID REZA. ROLE OF CALPAIN IN APOPTOSIS. CELL JOURNAL (YAKHTEH)[Internet]. 2011;13(2 (50)):65-72. Available from: https://sid.ir/paper/569664/en

IEEE: Copy

HAMID REZA MOMENI, “ROLE OF CALPAIN IN APOPTOSIS,” CELL JOURNAL (YAKHTEH), vol. 13, no. 2 (50), pp. 65–72, 2011, [Online]. Available: https://sid.ir/paper/569664/en

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