FREQUENCY-DEPENDENT ANTI ARRHYTHMIC EFFECTS OF CRATAEGUS MONOGYNA ON THE EXTRACELLULAR FIELD POTENTIAL RECORDINGS IN THE RABBIT ATRIOVENTRICULAR NODE, AN EXPERIMENTAL MODEL OF AF

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KHORI VAHID; AZADBAKHT MOHAMMAD; NAYEBPOUR MOHSEN; JAMSHIDI AMIR HOSSEIN; POURABOUK MONA; MOHAMMAD ALIZADEH ALI; BADAGHABADI FAKHRI; CHANGIZI SHIMA; RAJAEI MARYAM

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Journal: Physiology and Pharmacology Year:2011 | Volume:15 | Issue:1 Page(s): 36-46

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Title

FREQUENCY-DEPENDENT ANTI ARRHYTHMIC EFFECTS OF CRATAEGUS MONOGYNA ON THE EXTRACELLULAR FIELD POTENTIAL RECORDINGS IN THE RABBIT ATRIOVENTRICULAR NODE, AN EXPERIMENTAL MODEL OF AF

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HYDROALCOHOLIC EXTRACT OF C. MONOGYNA

RATE-DEPENDENT PROPERTIES

ZONE OF CONCEALMENT

Abstract

Introduction: Despite extensive studies that have been performed on the effects of Crataegus monogyna in cardiovascular diseases, only few investigations have addressed the antiarrhythmic properties of this plant. Aims of the present study were: 1) To determine the protective role of methanolic extract ofC. monogyna on the rate-dependent model and the concealed conduction of the AV node.2) To explore the role of Na+-K+ATPase in the protective role of C. monogyna Methods: Male New Zealand rabbits (1.5-2kg) were used in all experiments. Stimulation protocols were used to measure basic and rate-dependent AV nodal properties (recovery, atrial fibrilation and ZONE OF CONCEALMENT) in two groups (N=14). In the first group, all the stimulation protocols were performed before and after the administration of different concentrations ofC. monogyna extract (n=7), while in the second group (n=7), all stimulation protocols were carried out in the presence of ouabaine (0.05mM) and the plant extract.Results: Basic and RATE-DEPENDENT PROPERTIES of the AV node were inhibited after the addition of the extract of C.monogynato Kerebs Henselite solution. At the maximum concentration of C. monogyna (30 mg/l), WBCL cycle length was significantly increased from 156.5±3.4 to 173±5.8 ms and the nodal functional refractory period was prolonged from 164.4±4.1 to 182.7±3.8 ms (P <0.05). Significant decreases of ventricular rhythm were recorded in both selective concentrations of the plant extract. The depressant electrophysiological effect ofC. monogyna on the AV node was not abolished by ouabaine, a selective inhibitor of Na+-K+ATPase enzyme.Conclusion: The results showed a potential anti-arrhythmic and protective effect for C. monogyna. The effect of the plant extract in increasing nodal refractory period and widening of the concealment zone might be the major mechanisms involved. The protective role of C. monogyna was not related to the Na+-K+ATPase activity.

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APA: Copy

KHORI, VAHID, AZADBAKHT, MOHAMMAD, NAYEBPOUR, MOHSEN, JAMSHIDI, AMIR HOSSEIN, POURABOUK, MONA, MOHAMMAD ALIZADEH, ALI, BADAGHABADI, FAKHRI, CHANGIZI, SHIMA, & RAJAEI, MARYAM. (2011). FREQUENCY-DEPENDENT ANTI ARRHYTHMIC EFFECTS OF CRATAEGUS MONOGYNA ON THE EXTRACELLULAR FIELD POTENTIAL RECORDINGS IN THE RABBIT ATRIOVENTRICULAR NODE, AN EXPERIMENTAL MODEL OF AF. PHYSIOLOGY AND PHARMACOLOGY, 15(1), 36-46. SID. https://sid.ir/paper/569726/en

Vancouver: Copy

KHORI VAHID, AZADBAKHT MOHAMMAD, NAYEBPOUR MOHSEN, JAMSHIDI AMIR HOSSEIN, POURABOUK MONA, MOHAMMAD ALIZADEH ALI, BADAGHABADI FAKHRI, CHANGIZI SHIMA, RAJAEI MARYAM. FREQUENCY-DEPENDENT ANTI ARRHYTHMIC EFFECTS OF CRATAEGUS MONOGYNA ON THE EXTRACELLULAR FIELD POTENTIAL RECORDINGS IN THE RABBIT ATRIOVENTRICULAR NODE, AN EXPERIMENTAL MODEL OF AF. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2011;15(1):36-46. Available from: https://sid.ir/paper/569726/en

IEEE: Copy

VAHID KHORI, MOHAMMAD AZADBAKHT, MOHSEN NAYEBPOUR, AMIR HOSSEIN JAMSHIDI, MONA POURABOUK, ALI MOHAMMAD ALIZADEH, FAKHRI BADAGHABADI, SHIMA CHANGIZI, and MARYAM RAJAEI, “FREQUENCY-DEPENDENT ANTI ARRHYTHMIC EFFECTS OF CRATAEGUS MONOGYNA ON THE EXTRACELLULAR FIELD POTENTIAL RECORDINGS IN THE RABBIT ATRIOVENTRICULAR NODE, AN EXPERIMENTAL MODEL OF AF,” PHYSIOLOGY AND PHARMACOLOGY, vol. 15, no. 1, pp. 36–46, 2011, [Online]. Available: https://sid.ir/paper/569726/en

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