NEW METHOD FOR AUTOMATIC PREPARATION AND EVALUATION OF [111IN] -OXINATE COMPLEXES AS IMAGING AGENTS BY PROGRAMMING LOGIC CONTROL (PLC)

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BAHRAMI ABBAS; MIRZAII MOHAMMAD; FAZAELI YOUSEF; RAHIMINEJAD KISOMI ALI; YOUSEFI MOJIR KAMRAN; AGHIGHI KOROUSH

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Journal: Iranian Journal of Nuclear Medicine Year:2010 | Volume:18 | Issue:SUPPLEMENT 1 Page(s): 136-136

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Title

NEW METHOD FOR AUTOMATIC PREPARATION AND EVALUATION OF [111IN] -OXINATE COMPLEXES AS IMAGING AGENTS BY PROGRAMMING LOGIC CONTROL (PLC)

Author(s)

Keywords

PLC

AUTOMATION

111IN

Abstract

Introduction: The interesting physical assets and accessibility of indium-111 make it an engrossing radioisotope for radiopharmaceutical research [1-2]. The increasing trend in the production and use of PET radionuclides in nuclear medicine has offered new opportunities for researchers to focus on new methods for production of radiopharmaceuticals for their future PET radio nuclides. In this way, AUTOMATION and use of computers, PLCs, sensors, electronic boards are favor to manual production line and so our aim is to develop the present AMIRS' production line of Indium-111 oxyquinoline by PLCs. key words: [111In] -Oxinate, imaging agents, Automatic Preparation, PLCMethods: Indium-111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radio labeling autologous leukocytes. [111In] -Oxinate is the Agricultural, Medical and Industrial Research School (AMIRS) product that supplied as a sterile, non-pyrogenic, isotonic aqueous solution with a pH range of 6.5 to 7.5. The radionuclide impurity limit for indium 114m is not greater than 37kBq, per 37 MBq, of indium 111 at the time of calibration. All steps of the process were carried out manually and hence it increases the risk of human mistakes. In this work, the Indium-111 oxyquinoline production line is redesigned by using mini Logo PLC to decrease the role of human operating to produce medical drugs in a precision and repeatable manner.Results: By means of PLC's total production it minimizes radiation exposure to production line personnel and minimum adequate shielding of the preparation that must be maintained at all the production time. Accurate amounts of HBr are used and so the final products have accurate PH as programmed in PLCs.Conclusion: This study was conducted to investigate and illustrate the use of PLC's in production of [111In] - Oxinate Complexes as imaging agents. Through the automatic production we obtain high quality radiopharmaceutical with low cost and minimum waste produced.

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APA: Copy

BAHRAMI, ABBAS, MIRZAII, MOHAMMAD, FAZAELI, YOUSEF, RAHIMINEJAD KISOMI, ALI, YOUSEFI MOJIR, KAMRAN, & AGHIGHI, KOROUSH. (2010). NEW METHOD FOR AUTOMATIC PREPARATION AND EVALUATION OF [¹¹¹IN] -OXINATE COMPLEXES AS IMAGING AGENTS BY PROGRAMMING LOGIC CONTROL (PLC). IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(SUPPLEMENT 1), 136-136. SID. https://sid.ir/paper/570891/en

Vancouver: Copy

BAHRAMI ABBAS, MIRZAII MOHAMMAD, FAZAELI YOUSEF, RAHIMINEJAD KISOMI ALI, YOUSEFI MOJIR KAMRAN, AGHIGHI KOROUSH. NEW METHOD FOR AUTOMATIC PREPARATION AND EVALUATION OF [¹¹¹IN] -OXINATE COMPLEXES AS IMAGING AGENTS BY PROGRAMMING LOGIC CONTROL (PLC). IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(SUPPLEMENT 1):136-136. Available from: https://sid.ir/paper/570891/en

IEEE: Copy

ABBAS BAHRAMI, MOHAMMAD MIRZAII, YOUSEF FAZAELI, ALI RAHIMINEJAD KISOMI, KAMRAN YOUSEFI MOJIR, and KOROUSH AGHIGHI, “NEW METHOD FOR AUTOMATIC PREPARATION AND EVALUATION OF [¹¹¹IN] -OXINATE COMPLEXES AS IMAGING AGENTS BY PROGRAMMING LOGIC CONTROL (PLC),” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. SUPPLEMENT 1, pp. 136–136, 2010, [Online]. Available: https://sid.ir/paper/570891/en

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