INTERLEUKIN-8-251 A/T AND CXCR2 +1208 C/T GENES POLYMORPHISMS IN CHRONIC RHINOSINUSITIS

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KHADEMI BIJAN; DASTGHEIB SEYED HOSSEIN; KAMALI SARVESTANI ESKANDAR

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Journal Paper

Paper Information

Journal: Iranian Journal of Otorhinolaryngology Year:2011 | Volume:23 | Issue:3 (62) Page(s): 29-36

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Title

INTERLEUKIN-8-251 A/T AND CXCR2 +1208 C/T GENES POLYMORPHISMS IN CHRONIC RHINOSINUSITIS

Author(s)

KHADEMI BIJAN | DASTGHEIB SEYED HOSSEIN | KAMALI SARVESTANI ESKANDAR | Issue Writer Certificate

Keywords

CHRONIC RHINOSINUSITIS

CXCR2

INTERLEUKINL-8

NASAL POLYPOSIS

POLYMORPHISM

Abstract

Introduction: IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of CHRONIC RHINOSINUSITIS (CRS) as well as NASAL POLYPOSIS (NP) . The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T POLYMORPHISM. Hence, the aim of the present study was to investigate the association between IL-8-251 A/T and CXCR2+1208 C/T genes POLYMORPHISMs and susceptibility to CRS and NP.Materials and Methods: Two hundred and forty fiveCRS patients and 204 healthy controls were included in this study. CRS patients were categorized by the existence or absence of NP. IL-8 promoter-251 A/T and CXCR2+1208 C/T gene POLYMORPHISMs were genotyped via the allele specific PCR (AS-PCR) method.Results: While no remarkable difference was demonstrated between patients and controls for both CXCR2+1208 C/T and IL-8 -251 A/T POLYMORPHISMs, a significant increase in IL-8-251 AA genotype was detected in CRS patients with NP compared to those without it (29.3% and 16.2%, respectively; P=0.03) . Interestingly, this association got far stronger when only non-asthmatic CRS patients were taken into consideration (P=0.001) .Conclusion: The results of the present study indicate that the inheritance of IL-8-251 Aallele is associated significantly with NP development in CRS patients. Therefore, NP formation might be a result of the exposure to an intense inflammatory environment, which is more likely in genetically susceptible CRS patients.

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APA: Copy

KHADEMI, BIJAN, DASTGHEIB, SEYED HOSSEIN, & KAMALI SARVESTANI, ESKANDAR. (2011). INTERLEUKIN-8-251 A/T AND CXCR2 +1208 C/T GENES POLYMORPHISMS IN CHRONIC RHINOSINUSITIS. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, 23(3 (62)), 29-36. SID. https://sid.ir/paper/571086/en

Vancouver: Copy

KHADEMI BIJAN, DASTGHEIB SEYED HOSSEIN, KAMALI SARVESTANI ESKANDAR. INTERLEUKIN-8-251 A/T AND CXCR2 +1208 C/T GENES POLYMORPHISMS IN CHRONIC RHINOSINUSITIS. IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY[Internet]. 2011;23(3 (62)):29-36. Available from: https://sid.ir/paper/571086/en

IEEE: Copy

BIJAN KHADEMI, SEYED HOSSEIN DASTGHEIB, and ESKANDAR KAMALI SARVESTANI, “INTERLEUKIN-8-251 A/T AND CXCR2 +1208 C/T GENES POLYMORPHISMS IN CHRONIC RHINOSINUSITIS,” IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY, vol. 23, no. 3 (62), pp. 29–36, 2011, [Online]. Available: https://sid.ir/paper/571086/en

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