EFFICACY OF HESA-A IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS

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BARIKBIN B.; GHEYSARI MAHDI; SAEIDI MARJAN; ESMAEILI AZAD M.; MORAVEJ HAMIDEH; YOUSEFI MARYAM; AHMADI AMR ELAH

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Journal: IRANIAN JOURNAL OF DERMATOLOGY Year:2010 | Volume:13 | Issue:1 (51) Page(s): 16-19

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Title

EFFICACY OF HESA-A IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS

Author(s)

Keywords

PSORIASIS

HESA-A

HERBAL MEDICINE

Abstract

Background: Psoriasis is a common inflammatory skin disorder. There has been considerable interest in herbal medicine as a treatment for psoriasis. In a previous study HESA-A, a marine-herbal drug, was found to be beneficial in the treatment of psoriasis vulgaris. The aim of this study was to assess the efficacy and tolerability of HESA-A in patients with psoriasis.Methods: Nineteen patients with a mean PASI score of 13.04±6.14 (min=3.90, max=27.70) were recruited to receive daily dosage of 30 mg/kg of HESA-A tablets for at least 4 weeks. The patients were followed every two weeks for determining PASI score changes and drug side effects until the end of the study.Result: At the end of the study, the mean PASI score of the patients reduced to 9.60±5.30 (min=0.90, max=19.1). PASI score reduced in 14 patients (73.7%) and increased in 5 patients (26.3%) during the study. Two patients achieved 75 to 100% improvement in PASI score and two achieved 50 to 75%. In 10 patients (52.6%), 1 to 50% improvement in the PASI score was detected. There was a statically significant correlation between the duration of treatment and PASI improvement. (P-value=0.024)Conclusion: Although this drug was very safe and tolerable, our study did not find rapid and acceptable efficacy in the treatment of chronic plaque psoriasis as shown in a previous study. According to our findings, HESA-A was more effective when used for a prolonged time and in respect of the safety profile of HESA-A, we can use this drug as a maintenance or adjuvant therapy for chronic plaque psoriasis in longer terms

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APA: Copy

BARIKBIN, B., GHEYSARI, MAHDI, SAEIDI, MARJAN, ESMAEILI AZAD, M., MORAVEJ, HAMIDEH, YOUSEFI, MARYAM, & AHMADI, AMR ELAH. (2010). EFFICACY OF HESA-A IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS. IRANIAN JOURNAL OF DERMATOLOGY, 13(1 (51)), 16-19. SID. https://sid.ir/paper/571233/en

Vancouver: Copy

BARIKBIN B., GHEYSARI MAHDI, SAEIDI MARJAN, ESMAEILI AZAD M., MORAVEJ HAMIDEH, YOUSEFI MARYAM, AHMADI AMR ELAH. EFFICACY OF HESA-A IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2010;13(1 (51)):16-19. Available from: https://sid.ir/paper/571233/en

IEEE: Copy

B. BARIKBIN, MAHDI GHEYSARI, MARJAN SAEIDI, M. ESMAEILI AZAD, HAMIDEH MORAVEJ, MARYAM YOUSEFI, and AMR ELAH AHMADI, “EFFICACY OF HESA-A IN THE TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 13, no. 1 (51), pp. 16–19, 2010, [Online]. Available: https://sid.ir/paper/571233/en

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