HEPATIC INVOLVEMENT IN DENGUE FEVER IN CHILDREN

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JAGADISHKUMAR KALENAHALLI; JAIN PUJA; MANJUNATH VADDAMBAL G.; UMESH LINGAPPA

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Journal: Iranian Journal of Pediatrics Year:2012 | Volume:22 | Issue:2 Page(s): 231-236

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Title

HEPATIC INVOLVEMENT IN DENGUE FEVER IN CHILDREN

Author(s)

JAGADISHKUMAR KALENAHALLI | JAIN PUJA | MANJUNATH VADDAMBAL G. | UMESH LINGAPPA | Issue Writer Certificate

Keywords

DENGUE

HEPATOMEGALY

LIVER ENZYMES

CHILDREN

JAUNDICE

Abstract

Objective: Hepatic dysfunction is common in DENGUE infection and the degree of liver dysfunction in CHILDREN varies from mild injury with elevation of transaminases to severe injury with JAUNDICE. This study was undertaken to assess the spectrum of hepatic involvement in DENGUE infection.Methods: 110 CHILDREN with serologically positive DENGUE fever aged between 2 months -14 years were studied for their hepatic functions both clinically and biochemically after excluding malaria, enteric fever, Hepatitis A and Hepatitis B with relevant investigations.Findings: All cases were grouped into DF (DENGUE fever), DHF (DENGUE hemorrhagic fever) and DSS (DENGUE shock syndrome)according to WHO criteria. The spectrum of hepatic manifestations included HEPATOMEGALY (79%), hepatic tenderness (56%), JAUNDICE (4.5%), raised levels of aspartate transaminase (AST) (93 %), alanine transaminase (ALT) (78%), alkaline phosphatase (AP) (57%), prolonged prothrombin time (PT) (20%), reduced levels of serum albumin (66%) and abnormal abdomen ultrasound (65%).Conclusion: Hepatic dysfunction was observed more in DHF and DSS group compared to DF group. About 17.27% of CHILDREN had>10 fold increase in the LIVER ENZYMES. There was no correlation between the degree of hepatic enlargement or hepatic tenderness with the abnormalities of liver functions. Any child with fever, JAUNDICE and tender HEPATOMEGALY in geographical areas where DENGUE is endemic, the diagnosis of DENGUE infection should be strongly considered.

Cites

SERUM AMINOTRANSFERASES IN THAI CHILDREN WITH DENGUE INFECTION

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APA: Copy

JAGADISHKUMAR, KALENAHALLI, JAIN, PUJA, MANJUNATH, VADDAMBAL G., & UMESH, LINGAPPA. (2012). HEPATIC INVOLVEMENT IN DENGUE FEVER IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS, 22(2), 231-236. SID. https://sid.ir/paper/571918/en

Vancouver: Copy

JAGADISHKUMAR KALENAHALLI, JAIN PUJA, MANJUNATH VADDAMBAL G., UMESH LINGAPPA. HEPATIC INVOLVEMENT IN DENGUE FEVER IN CHILDREN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2012;22(2):231-236. Available from: https://sid.ir/paper/571918/en

IEEE: Copy

KALENAHALLI JAGADISHKUMAR, PUJA JAIN, VADDAMBAL G. MANJUNATH, and LINGAPPA UMESH, “HEPATIC INVOLVEMENT IN DENGUE FEVER IN CHILDREN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 22, no. 2, pp. 231–236, 2012, [Online]. Available: https://sid.ir/paper/571918/en

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