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Information Journal Paper

Title

SERUM AMINOTRANSFERASES IN THAI CHILDREN WITH DENGUE INFECTION

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Abstract

 Background: Hepatic manifestations are one of the unusual manifestations of DENGUE INFECTION.Objectives: We conducted this study in order to study the pattern of SERUM AMINOTRANSFERASES and sequential changes before and after shock in Thai children with DENGUE INFECTION.Patients and Methods: Children who were clinically and serologically diagnosed as DENGUE INFECTION and were admitted to King Chulalongkorn Memorial Hospital during a peroid of one year were enrolled. They were clinically classified into a non-shock group and a shock group. The majority of SERUM AMINOTRANSFERASES including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were obtained within a week after the onset of fever and until 3 days after shock in the shock group. Student t-test and median in boxplot form were used for statistical analysis.Results: We enrolled 127 children with a mean age of 7.6±3.6 years. The incidence of abnormal AST and ALT levels was 97.4% and 50.0% in the shock group, and 91.8% and 44.9% in the non-shock group respectively. 29% and 15.4% of the patients in shock group and only 10.2% and 4.1% in non-shock group had the respective AST and ALT levels>200 U/L. Serum aminotransferase levels were significantly higher in the shock group when compared to the non-shock group. AST tended to increase starting from one day before shock and continued to increase within a few days whereas ALT was less likely to be affected.Conclusions: Elevated SERUM AMINOTRANSFERASES are a common finding in children with DENGUE INFECTION and the levels of AST are higher than those of ALT. Patients with shock have significantly higher aminotransferase levels that increase up to 3 days after shock.

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    APA: Copy

    PROMMALIKIT, OLARN, THISYAKORN, USA, & THISYAKORN, CHULE. (2015). SERUM AMINOTRANSFERASES IN THAI CHILDREN WITH DENGUE INFECTION. IRANIAN JOURNAL OF PEDIATRICS, 25(6), 0-0. SID. https://sid.ir/paper/677780/en

    Vancouver: Copy

    PROMMALIKIT OLARN, THISYAKORN USA, THISYAKORN CHULE. SERUM AMINOTRANSFERASES IN THAI CHILDREN WITH DENGUE INFECTION. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(6):0-0. Available from: https://sid.ir/paper/677780/en

    IEEE: Copy

    OLARN PROMMALIKIT, USA THISYAKORN, and CHULE THISYAKORN, “SERUM AMINOTRANSFERASES IN THAI CHILDREN WITH DENGUE INFECTION,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 6, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/677780/en

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