EXPRESSION OF THE APOPTOSIS INHIBITOR BCL-2 IN SPUTUM EOSINOPHILS IN PATIENTS WITH ASTHMA

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AZIMI GH.; AMINI H.; ANDALIBI N.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2010 | Volume:5 | Issue:1 Page(s): 18-21

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Title

EXPRESSION OF THE APOPTOSIS INHIBITOR BCL-2 IN SPUTUM EOSINOPHILS IN PATIENTS WITH ASTHMA

Author(s)

AZIMI GH. | AMINI H. | ANDALIBI N. | Issue Writer Certificate

Keywords

APOPTOSIS

ASTHMA

B-BCL-2 PROTEINS

EOSINOPHIL

SPUTUM

Abstract

Background and Objectives: APOPTOSIS of EOSINOPHILs is of significant value in assessing the airway inflammation in patients with ASTHMA. Our purpose was to investigate the degree of expression of the Bcl-2 protein in SPUTUM EOSINOPHILs during acute ASTHMA exacerbation and its relationship with exacerbation severity. Materials and Methods: The study was carried out in Mostafa Khomeini Hospital, Tehran, Iran in March 2008. SPUTUM was obtained from 15 ASTHMAtic patients and 13 healthy subjects as a control group. Number of EOSINOPHILs was counted and Bcl-2+ EOSINOPHILs were stained using immunocytochemistry. Results: SPUTUM EOSINOPHILs and Bcl-2+ EOSINOPHILs were significantly higher in patients with acute exacerbation than controls (P<0.05). Conclusion: Bcl-2 prolongs survival and decreases APOPTOSIS of airway EOSINOPHILs during acute ASTHMA exacerbation. EOSINOPHIL APOPTOSIS and inhibition of Bcl-2 represent a target for new and effective therapeutic strategies of ASTHMA.

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APA: Copy

AZIMI, GH., AMINI, H., & ANDALIBI, N.. (2010). EXPRESSION OF THE APOPTOSIS INHIBITOR BCL-2 IN SPUTUM EOSINOPHILS IN PATIENTS WITH ASTHMA. IRANIAN JOURNAL OF PATHOLOGY (IJP), 5(1), 18-21. SID. https://sid.ir/paper/573328/en

Vancouver: Copy

AZIMI GH., AMINI H., ANDALIBI N.. EXPRESSION OF THE APOPTOSIS INHIBITOR BCL-2 IN SPUTUM EOSINOPHILS IN PATIENTS WITH ASTHMA. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2010;5(1):18-21. Available from: https://sid.ir/paper/573328/en

IEEE: Copy

GH. AZIMI, H. AMINI, and N. ANDALIBI, “EXPRESSION OF THE APOPTOSIS INHIBITOR BCL-2 IN SPUTUM EOSINOPHILS IN PATIENTS WITH ASTHMA,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 5, no. 1, pp. 18–21, 2010, [Online]. Available: https://sid.ir/paper/573328/en

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