EFFECT OF ANTI-MICROBIAL FIBER AND ITS INTERACTION WITH PENICILLIN G ON OPPORTUNISTIC SKIN MICRO-FLORA

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GHAZI ASGAR L.; KASRA KERMANSHAHI R.

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Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2008 | Volume:11 | Issue:1 (37) Page(s): 41-48

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Title

EFFECT OF ANTI-MICROBIAL FIBER AND ITS INTERACTION WITH PENICILLIN G ON OPPORTUNISTIC SKIN MICRO-FLORA

Author(s)

GHAZI ASGAR L. | KASRA KERMANSHAHI R. | Issue Writer Certificate

Keywords

ANTIMICROBIAL FIBERS

FRACTIONAL INHIBITORY CONCENTRATION (FIC)

MINIMAL INHIBITORY CONCENTRATION (MIC)

SKIN MICRO-FLORA

Abstract

Objective: The standard of hygiene in daily life and hospitals can be increased by the use of new ANTIMICROBIAL FIBERS, which diminish the danger of pathogenic bacteria. In this study, the antimicrobial effect of special fibers on some staphylococcus isolates was investigated.Materials and Methods: The antimicrobial effect of special type of fibers produced in Isfahan Poly Acryl Plant on three species of Staphylococcus aureus, epidermidis and lugdunensis isolated from 96 samples of hand and foot SKIN MICRO-FLORA was studied. The sensitivity of strains regarding resistant strains, to various antibiotics and beta-lactamase enzyme production was studied. The most resistance to antibiotics and beta-lactamase producer were chosen. Using the cup plate method, the inhibiting effect of pure antimicrobial agent on these strains was proven. Next, using shake flask method the effect of antimicrobial fiber on these strains was studied. In order to compare the effect of the antimicrobial agent of the fiber with that of penicillin G, the minimal inhibitory concentration (MIC) of the fiber antimicrobial agent and of penicillin G was tested on the strains. The effect of the interaction of these two antimicrobial agents and their fractional inhibitory concentration (FIC) on the chosen strains was studied using checkerboard method.Results: The results show a significant effect by antimicrobial fiber with 30%, 60% and 100% antimicrobial agent on Staphylococcus species after 24 hrs. Moreover despite the high level MIC of penicillin G on these bacteria (8-256 mg/ml), the MIC of the pure antimicrobial agent of fiber at a level of 10-4 ml/ml caused growth inhibition. The interaction of these two antibacterial agents on the chosen strains was evaluated as synergism.Conclusion: According to this study the antimicrobial effect of the fiber on growth inhibition of common, resistant skin bacterial flora is positive and therefore may be used after other successful clinical trials.

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APA: Copy

GHAZI ASGAR, L., & KASRA KERMANSHAHI, R.. (2008). EFFECT OF ANTI-MICROBIAL FIBER AND ITS INTERACTION WITH PENICILLIN G ON OPPORTUNISTIC SKIN MICRO-FLORA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 11(1 (37)), 41-48. SID. https://sid.ir/paper/575893/en

Vancouver: Copy

GHAZI ASGAR L., KASRA KERMANSHAHI R.. EFFECT OF ANTI-MICROBIAL FIBER AND ITS INTERACTION WITH PENICILLIN G ON OPPORTUNISTIC SKIN MICRO-FLORA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2008;11(1 (37)):41-48. Available from: https://sid.ir/paper/575893/en

IEEE: Copy

L. GHAZI ASGAR, and R. KASRA KERMANSHAHI, “EFFECT OF ANTI-MICROBIAL FIBER AND ITS INTERACTION WITH PENICILLIN G ON OPPORTUNISTIC SKIN MICRO-FLORA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 11, no. 1 (37), pp. 41–48, 2008, [Online]. Available: https://sid.ir/paper/575893/en

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