GLI 1 PROTEIN EXPRESSION IN DIFFERENT TYPES OF BASAL CELL CARCINOMA

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ANSARIN H.; FIROUZEH M.; SADEGHIPOUR A.R.; TAJZIEH CHI L.

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Journal Paper

Paper Information

Journal: Iranian Journal of Dermatology Year:2007 | Volume:10 | Issue:3 (41) Page(s): 211-218

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Title

GLI 1 PROTEIN EXPRESSION IN DIFFERENT TYPES OF BASAL CELL CARCINOMA

Author(s)

ANSARIN H. | FIROUZEH M. | SADEGHIPOUR A.R. | TAJZIEH CHI L. | Issue Writer Certificate

Keywords

BASAL CELL CARCINOMA GLI 1 PROTEINQ3

HEDGEHOG SIGNALQ3

Abstract

Background and aim: Basalcell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of HEDGEHOG SIGNAL is Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.Materials and methods: In this study 38 pathologic samples from patients with BCC were evaluated for expression of Gli 1. Results: In this study Gli 1 was most of time found in the nuclei and its expression was higher in invasive forms of BCC. We did not find any relationship between Gli 1 expression and location, recurrence, age, sexor history of radiotherapy in our patients. Conclusion: This study confirms the key role of Gli 1 in the pathogenesis of BCC. Gli 1 protein can help us to determine the prognosis.

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APA: Copy

ANSARIN, H., FIROUZEH, M., SADEGHIPOUR, A.R., & TAJZIEH CHI, L.. (2007). GLI 1 PROTEIN EXPRESSION IN DIFFERENT TYPES OF BASAL CELL CARCINOMA. IRANIAN JOURNAL OF DERMATOLOGY, 10(3 (41)), 211-218. SID. https://sid.ir/paper/57715/en

Vancouver: Copy

ANSARIN H., FIROUZEH M., SADEGHIPOUR A.R., TAJZIEH CHI L.. GLI 1 PROTEIN EXPRESSION IN DIFFERENT TYPES OF BASAL CELL CARCINOMA. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2007;10(3 (41)):211-218. Available from: https://sid.ir/paper/57715/en

IEEE: Copy

H. ANSARIN, M. FIROUZEH, A.R. SADEGHIPOUR, and L. TAJZIEH CHI, “GLI 1 PROTEIN EXPRESSION IN DIFFERENT TYPES OF BASAL CELL CARCINOMA,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 10, no. 3 (41), pp. 211–218, 2007, [Online]. Available: https://sid.ir/paper/57715/en

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