INTERFERON- Y PRODUCTION AND LEISHMANIN SKIN TEST IN NON-HEALING CUTANEOUS LEISHMANIASIS COMPARED WITH HEALED INDIVIDUALS

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MORTAZAVI H.; HALAJI Z.; KHAMESIPOUR A.; BAKHSHI H.; MIRAMIN MOHAMMADI A.

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Journal: Iranian Journal of Dermatology Year:2002 | Volume:5 | Issue:4 Page(s): 3-9

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Title

INTERFERON- Y PRODUCTION AND LEISHMANIN SKIN TEST IN NON-HEALING CUTANEOUS LEISHMANIASIS COMPARED WITH HEALED INDIVIDUALS

Author(s)

Keywords

LEISHMANIASISQ4

HEALINGQ3

INTERFERON-YQ4

Abstract

Background: Cutaneous LEISHMANIASIS (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent LEISHMANIASIS are defined as non-healing. Objectives: Comparison of the production of INTERFERON-Y (IFN-y) and leishmanin skin test (LST) between non-healing and healed patients of CL. Patients & Methods: Fifteen patients with non-healing CL suffering for more than two years, and eight individuals cured from CL were enrolled in this study. The rate of IFN-y production by peripheral blood mononuclear cells assessed by ELISA and results of LST were compared in both groups. Results: The mean level of IFN -y production in non-healing patients and cured individuals were 729 pg/ml, and 4229 pg/ml, respectively (t-test, P<0.01). Four patients in non-healing group had negative LST and all cured patients had positive LST. Conclusion: The low level of the IFN-y in non-healing patients and high level ofIFN-y in healed individuals are in favour of the lack of THI response, which is usually seen in healed patients. Comparing the results of LST between two groups is not conclusive.

Cites

SOLUBLE CD26 AND CD30 CONCENTRATION IN CUTANEOUS LEISHMANIASIS

References

مطالعه ایمنی شناسی درباره لیشمانیوز مقاوم و مزمن

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APA: Copy

MORTAZAVI, H., HALAJI, Z., KHAMESIPOUR, A., BAKHSHI, H., & MIRAMIN MOHAMMADI, A.. (2002). INTERFERON- Y PRODUCTION AND LEISHMANIN SKIN TEST IN NON-HEALING CUTANEOUS LEISHMANIASIS COMPARED WITH HEALED INDIVIDUALS . IRANIAN JOURNAL OF DERMATOLOGY, 5(4), 3-9. SID. https://sid.ir/paper/57790/en

Vancouver: Copy

MORTAZAVI H., HALAJI Z., KHAMESIPOUR A., BAKHSHI H., MIRAMIN MOHAMMADI A.. INTERFERON- Y PRODUCTION AND LEISHMANIN SKIN TEST IN NON-HEALING CUTANEOUS LEISHMANIASIS COMPARED WITH HEALED INDIVIDUALS . IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2002;5(4):3-9. Available from: https://sid.ir/paper/57790/en

IEEE: Copy

H. MORTAZAVI, Z. HALAJI, A. KHAMESIPOUR, H. BAKHSHI, and A. MIRAMIN MOHAMMADI, “INTERFERON- Y PRODUCTION AND LEISHMANIN SKIN TEST IN NON-HEALING CUTANEOUS LEISHMANIASIS COMPARED WITH HEALED INDIVIDUALS ,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 5, no. 4, pp. 3–9, 2002, [Online]. Available: https://sid.ir/paper/57790/en

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