EFFECTS OF NICOTINE ON SPERM CHARACTERISTICS AND FERTILITY PROFILE IN ADULT MALE RATS: A POSSIBLE ROLE OF CESSATION

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OYEYIPO IBUKUN PETER; RAJI YINUSA; EMIKPE BENJAMIN OBUKOWHO; BOLARINWA ADEYOMBO FOLASHADE

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Journal: Journal of Reproduction & Infertility Year:2011 | Volume:12 | Issue:3 (48) Page(s): 201-207

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Title

EFFECTS OF NICOTINE ON SPERM CHARACTERISTICS AND FERTILITY PROFILE IN ADULT MALE RATS: A POSSIBLE ROLE OF CESSATION

Author(s)

OYEYIPO IBUKUN PETER | RAJI YINUSA | EMIKPE BENJAMIN OBUKOWHO | BOLARINWA ADEYOMBO FOLASHADE | Issue Writer Certificate

Keywords

FERTILITY

LITTER WEIGHT

NICOTINE

RAT

SMOKING

SPERM

Abstract

Introduction: InFERTILITY is common among couples of child-bearing age and approximately half of known causes of primary inFERTILITY are attributable to male factor.It is still unclear whether the injurious effects of cigarette SMOKING on SPERM characteristics and inFERTILITY are due to NICOTINE. Therefore, the present study investtigated the effects of orally administered of NICOTINE on SPERM characteristics and libido in adult male albino RATs. The study also sought NICOTINE effects on FERTILITY RATe, litter size and weight in female animals cohabited with NICOTINE treated male RATs.Methods: Forty male and twenty-five female RATs were used for the study. The male RATs were divided into five groups and were treated for a period of 30 days with NICOTINE 0.5mg/kg (low dose) and 1.0 mg/kg (high dose) per body weight while the control RATs received 0.2ml/kg normal saline. The fourth and fifth groups were gavaged with 0.5mg/kg and 1.0 mg/kg body weight of NICOTINE but were left untreated for another 30 days. These groups served as the recovery groups. At the end of each experimental period, SPERM analysis, FERTILITY study, LITTER WEIGHT and size were determined.Results: SPERM motility and count significantly decreased (P<0.05) while the percentage of abnormality significantly increased (P<0.05) in both treatment groups.However, there was an insignificant decrease (P>0.05) in the viability and semen volume of the treated groups. FERTILITY studies revealed that NICOTINE reduced libido in male RATs, LITTER WEIGHT and number delivered by the untreated female during the experiments.Conclusion: The present study showed that NICOTINE has a dose-dependent deleterious effect on the SPERM characteristics and that FERTILITY is ameliorated by NICOTINE cessation in male RATs.

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APA: Copy

OYEYIPO, IBUKUN PETER, RAJI, YINUSA, EMIKPE, BENJAMIN OBUKOWHO, & BOLARINWA, ADEYOMBO FOLASHADE. (2011). EFFECTS OF NICOTINE ON SPERM CHARACTERISTICS AND FERTILITY PROFILE IN ADULT MALE RATS: A POSSIBLE ROLE OF CESSATION. JOURNAL OF REPRODUCTION AND INFERTILITY, 12(3 (48)), 201-207. SID. https://sid.ir/paper/578484/en

Vancouver: Copy

OYEYIPO IBUKUN PETER, RAJI YINUSA, EMIKPE BENJAMIN OBUKOWHO, BOLARINWA ADEYOMBO FOLASHADE. EFFECTS OF NICOTINE ON SPERM CHARACTERISTICS AND FERTILITY PROFILE IN ADULT MALE RATS: A POSSIBLE ROLE OF CESSATION. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2011;12(3 (48)):201-207. Available from: https://sid.ir/paper/578484/en

IEEE: Copy

IBUKUN PETER OYEYIPO, YINUSA RAJI, BENJAMIN OBUKOWHO EMIKPE, and ADEYOMBO FOLASHADE BOLARINWA, “EFFECTS OF NICOTINE ON SPERM CHARACTERISTICS AND FERTILITY PROFILE IN ADULT MALE RATS: A POSSIBLE ROLE OF CESSATION,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 12, no. 3 (48), pp. 201–207, 2011, [Online]. Available: https://sid.ir/paper/578484/en

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