EFFECTS OF A VOLTAGE SENSITIVE CALCIUM CHANNEL BLOCKER AND A SODIUM-CALCIUM EXCHANGER INHIBITOR ON APOPTOSIS OF MOTOR NEURONS IN ADULT SPINAL CORD SLICES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOMENI HAMID REZA; JARAHZADEH MAHSA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2012 | Volume:14 | Issue:3 (55) Page(s): 171-176

Download Full-Text

View:

371

Download:

253

Cites:

Information Journal Paper

Title

EFFECTS OF A VOLTAGE SENSITIVE CALCIUM CHANNEL BLOCKER AND A SODIUM-CALCIUM EXCHANGER INHIBITOR ON APOPTOSIS OF MOTOR NEURONS IN ADULT SPINAL CORD SLICES

Author(s)

MOMENI HAMID REZA | JARAHZADEH MAHSA | Issue Writer Certificate

Keywords

APOPTOSIS

BEPRIDIL

LOPERAMIDE

MOTOR NEURON

SPINAL CORD

Abstract

Objective: The APOPTOSIS of MOTOR NEURONs is a critical phenomenon in SPINAL CORD injuries. Adult SPINAL CORD slices were used to investigate whether voltage sensitive calcium channels and Na+/Ca2+ exchangers play a role in the APOPTOSIS of MOTOR NEURONs.Materials and Methods: In this experimental research, the thoracic region of the adult mouse SPINAL CORD was sliced using a tissue chopper and the slices were incubated in a culture medium in the presence or absence of N/L type voltage sensitive calcium channels blocker (loperamide, 100 mM) or Na+/Ca2+ exchangers inhibitor (bepridil, 20 mM) for 6 hours. 3- (4, 5-dimethylthiazol-2-yl) -2, 5 diphenyl tetrazolium (MTT) staining was used to assess slice viability while morphological features of APOPTOSIS in MOTOR NEURONs were studied using fluorescent staining.Results: After 6 hours in culture, LOPERAMIDEand BEPRIDIL not only increased slice viability, but also prevented MOTOR NEURON APOPTOSIS and significantly increased the percentage of viable MOTOR NEURONs in the ventral horns of the SPINAL CORD.Conclusion: The results of this study suggest that voltage sensitive calcium channels and Na+/Ca2+exchanger might be involved in the APOPTOSIS of MOTOR NEURONs in adult SPINAL CORD slices.

Cites

No record.

References

No record.

Cite

APA: Copy

MOMENI, HAMID REZA, & JARAHZADEH, MAHSA. (2012). EFFECTS OF A VOLTAGE SENSITIVE CALCIUM CHANNEL BLOCKER AND A SODIUM-CALCIUM EXCHANGER INHIBITOR ON APOPTOSIS OF MOTOR NEURONS IN ADULT SPINAL CORD SLICES. CELL JOURNAL (YAKHTEH), 14(3 (55)), 171-176. SID. https://sid.ir/paper/579107/en

Vancouver: Copy

MOMENI HAMID REZA, JARAHZADEH MAHSA. EFFECTS OF A VOLTAGE SENSITIVE CALCIUM CHANNEL BLOCKER AND A SODIUM-CALCIUM EXCHANGER INHIBITOR ON APOPTOSIS OF MOTOR NEURONS IN ADULT SPINAL CORD SLICES. CELL JOURNAL (YAKHTEH)[Internet]. 2012;14(3 (55)):171-176. Available from: https://sid.ir/paper/579107/en

IEEE: Copy

HAMID REZA MOMENI, and MAHSA JARAHZADEH, “EFFECTS OF A VOLTAGE SENSITIVE CALCIUM CHANNEL BLOCKER AND A SODIUM-CALCIUM EXCHANGER INHIBITOR ON APOPTOSIS OF MOTOR NEURONS IN ADULT SPINAL CORD SLICES,” CELL JOURNAL (YAKHTEH), vol. 14, no. 3 (55), pp. 171–176, 2012, [Online]. Available: https://sid.ir/paper/579107/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops