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Information Journal Paper

Title

EFFECT OF A NEW SYNBIOTIC MIXTURE ON ATOPIC DERMATITIS IN CHILDREN: A RANDOMIZED-CONTROLLED TRIAL

Pages

  225-230

Abstract

 Objective: ATOPIC DERMATITIS (AD) is the most common chronic relapsing skin disease seen in infancy and childhood. The intestinal microbiota play an important role in immune development and may play a role in the development of allergic disorders. Manipulation of the intestinal microbiota by SYNBIOTICs may therefore offer an approach to the prevention or treatment of AD and allergic diseases. We studied the clinical and immunologic effects of a new symbiotic (a mixture of seven probiotic strains of bacteria and Fructooligosaccharide) in infants and CHILDREN with AD.Methods: In a randomized, double-blind, placebo-controlled study, 40 infants and CHILDREN aged 3 months to 6 years with AD received either a SYNBIOTIC or placebo for 8 weeks. The Severity Scoring of ATOPIC DERMATITIS (SCORAD) index was recorded at baseline and also at 4 and 8 weeks of treatment.Findings: There was no significant difference between the probiotic and placebo group in baseline characteristics including sex, age, family history, corticosteroid usage and prick testing. Mean age was 23 months. The SYNBIOTIC group showed a significantly greater reduction in SCORAD than did the placebo group (P=0.001). No specific effect was demonstrated of the probiotics employed on CYTOKINE profile (P=0.4, P=0.6). Egg white was the most common (45%) allergen followed by peanut and cow’s milk.Conclusion: This study provides evidence that a mixture of seven strains of probiotics and Fructooligosaccharide can clinically improve the severity of AD in young CHILDREN. Further studies are needed to investigate the effects on underlying immune responses and the potential long term benefits for patients with AD.

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    APA: Copy

    FARID, REZA, AHANCHIAN, HAMID, JABBARI, FARAHZAD, & MOGHIMAN, TOKTAM. (2011). EFFECT OF A NEW SYNBIOTIC MIXTURE ON ATOPIC DERMATITIS IN CHILDREN: A RANDOMIZED-CONTROLLED TRIAL. IRANIAN JOURNAL OF PEDIATRICS, 21(2), 225-230. SID. https://sid.ir/paper/580080/en

    Vancouver: Copy

    FARID REZA, AHANCHIAN HAMID, JABBARI FARAHZAD, MOGHIMAN TOKTAM. EFFECT OF A NEW SYNBIOTIC MIXTURE ON ATOPIC DERMATITIS IN CHILDREN: A RANDOMIZED-CONTROLLED TRIAL. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2011;21(2):225-230. Available from: https://sid.ir/paper/580080/en

    IEEE: Copy

    REZA FARID, HAMID AHANCHIAN, FARAHZAD JABBARI, and TOKTAM MOGHIMAN, “EFFECT OF A NEW SYNBIOTIC MIXTURE ON ATOPIC DERMATITIS IN CHILDREN: A RANDOMIZED-CONTROLLED TRIAL,” IRANIAN JOURNAL OF PEDIATRICS, vol. 21, no. 2, pp. 225–230, 2011, [Online]. Available: https://sid.ir/paper/580080/en

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