MOLECULAR EPIDEMIOLOGY OF ROTAVIRUS STRAINS CIRCULATING AMONG CHILDREN WITH GASTROENTERITIS IN IRAN

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KARGAR MOHAMMAD; ZARE MARYAM; NAJAFI AKRAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Pediatrics Year:2012 | Volume:22 | Issue:1 Page(s): 63-69

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Information Journal Paper

Title

MOLECULAR EPIDEMIOLOGY OF ROTAVIRUS STRAINS CIRCULATING AMONG CHILDREN WITH GASTROENTERITIS IN IRAN

Author(s)

KARGAR MOHAMMAD | ZARE MARYAM | NAJAFI AKRAM | Issue Writer Certificate

Keywords

ROTAVIRUS

GASTROENTERITIS

GENOTYPING

CHILDREN

EPIDEMIOLOGY

Abstract

Objective: This study was conducted to evaluate the prevalence of ROTAVIRUS disease and to investigate the genotypes of ROTAVIRUS strains causing acute GASTROENTERITIS among CHILDREN aged<5 years old in Marvdasht, Iran.Methods: One hundred and forty-one CHILDREN, aged 1 month to 5 years, afflicted with severe diarrhea were enrolled during January 2007 to December 2008. Their stool samples were studied with enzyme immunoassays (EIA) for group A ROTAVIRUSes. ROTAVIRUS-positive specimens were genotyped by the Nested RT-PCR using different types of specific primers.Findings: Out of total collected samples ROTAVIRUS infection was detected in 40 (28.37%). Of the ROTAVIRUS episodes, 72.91% occurred during the first 2 years of life (P =0.038).The highest prevalence of infection was identified in summer (52.50%) and the lowest in winter (7.50%). The most common clinical features included diarrhea (96.25%), vomiting (82.50%) and fever (45.0%). Mixed genotypes were the predominant G type (60.0%), followed by non-typeable (12.50%), G2 (12.50%), G4 (10.0%) and G1 (5.0%) genotypes. G3/G8 mixed infection is the first of these ROTAVIRUS genotypes to be reported in Iran.Conclusion: Regarding high frequency of ROTAVIRUS infection, continuous surveillance is needed to inform diarrhea prevention programs as well as to provide information about the occurrence of new ROTAVIRUS strains. This will assist policy makers in decision making on ROTAVIRUS vaccine introduction.

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APA: Copy

KARGAR, MOHAMMAD, ZARE, MARYAM, & NAJAFI, AKRAM. (2012). MOLECULAR EPIDEMIOLOGY OF ROTAVIRUS STRAINS CIRCULATING AMONG CHILDREN WITH GASTROENTERITIS IN IRAN. IRANIAN JOURNAL OF PEDIATRICS, 22(1), 63-69. SID. https://sid.ir/paper/580262/en

Vancouver: Copy

KARGAR MOHAMMAD, ZARE MARYAM, NAJAFI AKRAM. MOLECULAR EPIDEMIOLOGY OF ROTAVIRUS STRAINS CIRCULATING AMONG CHILDREN WITH GASTROENTERITIS IN IRAN. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2012;22(1):63-69. Available from: https://sid.ir/paper/580262/en

IEEE: Copy

MOHAMMAD KARGAR, MARYAM ZARE, and AKRAM NAJAFI, “MOLECULAR EPIDEMIOLOGY OF ROTAVIRUS STRAINS CIRCULATING AMONG CHILDREN WITH GASTROENTERITIS IN IRAN,” IRANIAN JOURNAL OF PEDIATRICS, vol. 22, no. 1, pp. 63–69, 2012, [Online]. Available: https://sid.ir/paper/580262/en

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