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Information Journal Paper

Title

COMPARTMENTS OF QUERCETIN & ALLIUM CEPA (ONION) ON BLOOD GLUCOSE IN DIABETIC RATS

Pages

  107-112

Keywords

RAT 

Abstract

 Background: The major concern in DIABETES is increased oxidative stress. Maintaining a balance between reactive oxygen species (ROS) and antioxidants is a major mechanism in preventing damage from oxidative stress. QUERCETIN (QR) is a well-known flavonoid and a strong antioxidant derived from the ONION, Allium cepa, and it has been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced DIABETES in animals. Objective: We aimed to study on beneficial effects of QR & Allium cepa on regulation of blood glucose in diabetic model.Methods: Seventy male 8-week-old Wistar albino RATs weighing 250±10 g were obtained, the RATs were divided into seven groups comprising ten animals in each group. DIABETES induced with single intraperitoneal injection of STZ. Diabetic RATs treated with QUERCETIN (15mg/kg/day, started 48 hours after STZ injection) and Allium cepa juice (2cc/rat/day, started 48 hours after STZ injection). After 28 days treatment, analysis on blood glucose and insulin was done. Results: The mean TAC showed a significant increase (p<0.05) in the QR compared to the control, STZ and STZ+QR groups. Both QR and ONION Juice had significant effect in lowering blood glucose (355.3±104 mg/dl and 353.4±103 mg/dl respectively) (p<0.05) in STZ induced diabetic animals. Both QR and ONION juice had lowering effect in Serum insulin in healthy animals and significant increasing effect on serum insulin level in diabetic animals. Conclusions: Both QR and ONION juice had good effect in modifying DIABETES related biochemical parameters and they are recommended to be studied more in order to being used in the therapy.

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    APA: Copy

    KHAKI, A., FATHI AZAD, F., AHMADI ASHTIANI, H.R., REZAZADEH, SH., RASTEGAR, H., & IMANI, A.M.. (2010). COMPARTMENTS OF QUERCETIN & ALLIUM CEPA (ONION) ON BLOOD GLUCOSE IN DIABETIC RATS. JOURNAL OF MEDICINAL PLANTS, 9(SUPPLEMENT 6), 107-112. SID. https://sid.ir/paper/581654/en

    Vancouver: Copy

    KHAKI A., FATHI AZAD F., AHMADI ASHTIANI H.R., REZAZADEH SH., RASTEGAR H., IMANI A.M.. COMPARTMENTS OF QUERCETIN & ALLIUM CEPA (ONION) ON BLOOD GLUCOSE IN DIABETIC RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2010;9(SUPPLEMENT 6):107-112. Available from: https://sid.ir/paper/581654/en

    IEEE: Copy

    A. KHAKI, F. FATHI AZAD, H.R. AHMADI ASHTIANI, SH. REZAZADEH, H. RASTEGAR, and A.M. IMANI, “COMPARTMENTS OF QUERCETIN & ALLIUM CEPA (ONION) ON BLOOD GLUCOSE IN DIABETIC RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 9, no. SUPPLEMENT 6, pp. 107–112, 2010, [Online]. Available: https://sid.ir/paper/581654/en

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