ASSOCIATION BETWEEN INTERLEUKIN-28B GENETIC VARIANTS AND HEPATITIS C

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KHAJAVI REZVAN; RAFIEI ALIREZA; HAGHSHENAS MOHAMMAD REZA; HOSSEINI KHAH ZAHRA; SHARBAFI RAMISA

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:22 | Issue:95 Page(s): 19-27

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Title

ASSOCIATION BETWEEN INTERLEUKIN-28B GENETIC VARIANTS AND HEPATITIS C

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Keywords

IL-28B

POLYMORPHISM

HEPATITIS C INFECTION

Abstract

Background and purpose: Host genetic and environmental factors and factors associated with hepatitis C virus (HCV) play critical roles in development of the hepatitis. This study was performed to investigate the association between Interleukin- 28B (IL-28B) genetic variants and chronic hepatitis C.Materials and methods: This case-control study was conducted in 133 HCV-RNA positive patients attending two methadone treatment clinics, a hemophilia center, a thalassemia center and three dialysis center in Mazandaran province, Iran, 2010-2011. In addition, 173 HCV negative subjects were recruited as the controls. The two groups were matched for age, sex and geographic region. The IL-28B genotype at polymorphic site rs12979860 was determined by Tetra-ARMS-PCR method. Quantitative and qualitative data were analyzed using Student t and Chi square tests, respectively.Results: The mean age of patients with HCV (96 male, 27 female) was 36.38±12.49 years. The control group comprised 107 male and 66 female with the mean age of 38.27±11.27 years. The distribution of IL-28B genotypes did not differ between the two groups (P=0.008). On the other hand, the frequency of C/C, C/T and T/T genotypes were 41.4, 41.6 and 17.3% in experimental group and 42.5, 40.6, and 16.9% in the control group, respectively. The frequency of C and T alleles was not significantly different between the two groups (P=0.84).Conclusion: No significant difference was observed in the frequency of the rs12979860 POLYMORPHISM in upstream of IL-28B among HCV patients and control groups. According to the proven role of C allele in association with HCV treatment response it is assumed that genetic differences in IL-28B or IFN-l could predict treatment outcome.

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APA: Copy

KHAJAVI, REZVAN, RAFIEI, ALIREZA, HAGHSHENAS, MOHAMMAD REZA, HOSSEINI KHAH, ZAHRA, & SHARBAFI, RAMISA. (2012). ASSOCIATION BETWEEN INTERLEUKIN-28B GENETIC VARIANTS AND HEPATITIS C. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(95), 19-27. SID. https://sid.ir/paper/582474/en

Vancouver: Copy

KHAJAVI REZVAN, RAFIEI ALIREZA, HAGHSHENAS MOHAMMAD REZA, HOSSEINI KHAH ZAHRA, SHARBAFI RAMISA. ASSOCIATION BETWEEN INTERLEUKIN-28B GENETIC VARIANTS AND HEPATITIS C. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;22(95):19-27. Available from: https://sid.ir/paper/582474/en

IEEE: Copy

REZVAN KHAJAVI, ALIREZA RAFIEI, MOHAMMAD REZA HAGHSHENAS, ZAHRA HOSSEINI KHAH, and RAMISA SHARBAFI, “ASSOCIATION BETWEEN INTERLEUKIN-28B GENETIC VARIANTS AND HEPATITIS C,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 95, pp. 19–27, 2012, [Online]. Available: https://sid.ir/paper/582474/en

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