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Title

THERAPEUTIC EFFECT OF POSTERIOR SUB-TENON METHYL PREDNISOLONE IN ANTERIOR ISCHEMIC OPTIC NEUROPATHY: A RANDOMIZED CLINICAL TRIAL

Pages

  50-56

Abstract

 Purpose: To evaluate the therapeutic effect of posterior sub-tenon METHYL PREDNISOLONE in anterior ischemic optic neuropathy, No class 1 study has shown any conclusive medical or surgical treatment for non-arteritic anterior ischemic optic neuropathy (NAION). Efficacy of systemic or intravitreal steroids was suggested by some studies. This study was performed to evaluate the efficacy and safety of POSTERIOR SUB-TENON INJECTION of METHYL PREDNISOLONE in eyes with acute NAION.Methods: In a double blind randomized clinical trial, forty patients with a recent onset NAION were randomly assigned into case and control groups. The case group received a single POSTERIOR SUB-TENON INJECTION of 40 mg METHYL PREDNISOLONE; the control group received a sham injection. The patients had complete eye examination including visual field measurement and fluorescein angiography and systemic evaluation at the beginning. Eye examination was repeated at 2, 4, 6 and 8 week steps of the follow-up. Visual field was rechecked at the end of the follow-up. Statistical analysis used: SPSS 11.5 system, paired sample t-test; independent sample t-test, X2, and ANOVA.Results: Visual acuity (VA) improved 0.3 logMAR (three lines of Snellen chart) in the case group (P<0.030), no visual improvement was observed in the control group (P<0.589). Comparison between the two groups showed improvement in VA (P=0.021 at two weeks, and P=0.053 at 8 weeks), visual field pattern standard deviation (PSD), (P=0.034) and optic disc edema, (P=0.000) in the treatment group. No case of globe perforation or severe intraocular pressure (IOP) rise was detected.Conclusion: POSTERIOR SUB-TENON INJECTION of METHYL PREDNISOLONE was preferred to observation in acute NAION.

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    APA: Copy

    FESHARAKI, HAMID, KIANERSI, FARZAN, & SHOYOUKHI, SHAHIN. (2011). THERAPEUTIC EFFECT OF POSTERIOR SUB-TENON METHYL PREDNISOLONE IN ANTERIOR ISCHEMIC OPTIC NEUROPATHY: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF CURRENT OPHTHALMOLOGY, 23(3), 50-56. SID. https://sid.ir/paper/582607/en

    Vancouver: Copy

    FESHARAKI HAMID, KIANERSI FARZAN, SHOYOUKHI SHAHIN. THERAPEUTIC EFFECT OF POSTERIOR SUB-TENON METHYL PREDNISOLONE IN ANTERIOR ISCHEMIC OPTIC NEUROPATHY: A RANDOMIZED CLINICAL TRIAL. JOURNAL OF CURRENT OPHTHALMOLOGY[Internet]. 2011;23(3):50-56. Available from: https://sid.ir/paper/582607/en

    IEEE: Copy

    HAMID FESHARAKI, FARZAN KIANERSI, and SHAHIN SHOYOUKHI, “THERAPEUTIC EFFECT OF POSTERIOR SUB-TENON METHYL PREDNISOLONE IN ANTERIOR ISCHEMIC OPTIC NEUROPATHY: A RANDOMIZED CLINICAL TRIAL,” JOURNAL OF CURRENT OPHTHALMOLOGY, vol. 23, no. 3, pp. 50–56, 2011, [Online]. Available: https://sid.ir/paper/582607/en

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