THE INHIBITORY EFFECT OF ARTEMISIA ANNUA EXTRACTS ON GASTRIC CANCER CELLS VIA APOPTOSIS INDUCTION

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EMAMI AHMAD; ZAMANI TAGHIZADEH RABE SH.; AAHI A.; MAHMOUDI MAHMOUD

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Journal: Journal of Shahrekord University of Medical Sciences Year:2010 | Volume:11 | Issue:4 Page(s): 1-10

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Information Journal Paper

Title

THE INHIBITORY EFFECT OF ARTEMISIA ANNUA EXTRACTS ON GASTRIC CANCER CELLS VIA APOPTOSIS INDUCTION

Author(s)

EMAMI AHMAD | ZAMANI TAGHIZADEH RABE SH. | AAHI A. | MAHMOUDI MAHMOUD | Issue Writer Certificate

Keywords

APOPTOSISQ3

ARTEMISIA ANNUAQ1

CYTOTOXICITYQ3

GASTRIC CANCER CELL LINEQ3

Abstract

Background and aim: Previous studies have shown an anti-tumoral effect for different species of Artemisia. This study was performed to evaluate the anti-tumural effects of different kinds of ARTEMISIA ANNUA extracts on gastric cancer cells.Methods: Methanol, ethylacetate, dichloromethane and hexan extracts of ARTEMISIA ANNUA were prepared by step to step procedure. Cultivated GASTRIC CANCER CELL LINE (AGS) and normal fibroblast cells (L929) were incubated with different concentrations of extracts for 24 hours and cell growth inhibition was determined using MTT assay and results were reported as IC50 (concentration that caused 50 percent inhibition of cells growth). Annexin V and propidium iodide (PI) staining was used to evaluate the APOPTOSIS and/or necrosis induction in cancer cells. One way ANOVA was used for analysis.Results: The results obtained from MTT assay showed a strong and dose-dependent inhibition of cancer cell growth by different ARTEMISIA ANNUA extracts. The most cytotoxic effect was obtained by methanolic extract (IC50: 500 mg/ml) and it caused APOPTOSIS more than other extracts.Conclusion: Isolated extracts from ARTEMISIA ANNUA caused a significant decrease in gastric cancer cell growth mainly by induction of APOPTOSIS and at the same time they had less toxicity on normal cells. Therefore, Isolation and purification of effective compound/s from this extracts and determination of their mechanisms of action is suggested.

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APA: Copy

EMAMI, AHMAD, ZAMANI TAGHIZADEH RABE, SH., AAHI, A., & MAHMOUDI, MAHMOUD. (2010). THE INHIBITORY EFFECT OF ARTEMISIA ANNUA EXTRACTS ON GASTRIC CANCER CELLS VIA APOPTOSIS INDUCTION. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 11(4), 1-10. SID. https://sid.ir/paper/58345/en

Vancouver: Copy

EMAMI AHMAD, ZAMANI TAGHIZADEH RABE SH., AAHI A., MAHMOUDI MAHMOUD. THE INHIBITORY EFFECT OF ARTEMISIA ANNUA EXTRACTS ON GASTRIC CANCER CELLS VIA APOPTOSIS INDUCTION. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;11(4):1-10. Available from: https://sid.ir/paper/58345/en

IEEE: Copy

AHMAD EMAMI, SH. ZAMANI TAGHIZADEH RABE, A. AAHI, and MAHMOUD MAHMOUDI, “THE INHIBITORY EFFECT OF ARTEMISIA ANNUA EXTRACTS ON GASTRIC CANCER CELLS VIA APOPTOSIS INDUCTION,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 4, pp. 1–10, 2010, [Online]. Available: https://sid.ir/paper/58345/en

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