EVALUATION OF CANNABIS SATIVA LEAVES AQUATIC EXTRACT EFFECT ON TRIPLE REGIONS OF HIPPOCAMPUS NEURONAL DENSITY IN MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TEHRANIPOUR M.; KEHTARPOUR M.; JAVAD MOOSAVI B.Z.; MAHDAVI SHAHRI N.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2012 | Volume:14 | Issue:1 Page(s): 20-27

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,395

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF CANNABIS SATIVA LEAVES AQUATIC EXTRACT EFFECT ON TRIPLE REGIONS OF HIPPOCAMPUS NEURONAL DENSITY IN MALE RATS

Author(s)

TEHRANIPOUR M. | KEHTARPOUR M. | JAVAD MOOSAVI B.Z. | MAHDAVI SHAHRI N. | Issue Writer Certificate

Keywords

CANNABINOIDQ2

CANNABIS SATIVAQ2

HIPPCAMPUSQ2

MEMORYQ2

Abstract

Background and aims: More than sixty one substances have been found in CANNABIS SATIVA which are called CANNABINOIDs. CANNABINOIDs are involved in all stages of MEMORY. The aim of this study was to evaluate the effects of leaves aquatic extract of CANNABIS SATIVA on the neuronal density of CA1, CA2 and CA3 of Hippocampus in rats.Methods: In this experimental study twenty four male Wistar rats (weight 300-350 g) were divided into two experimental and one control groups. CANNABIS SATIVA was extracted with Soxhlet apparatus. Aquatic extract was injected introperitonealy (I.P.) in experimental groups with two dosages (50 mg/kg and 25 mg/kg) for three weeks. After one month, animals were decapitated and their brains were dissected, fixed in 10% formalin, sectioned in 7μm thickness and stained by hematoxin-eosin (HE). By applying dissector techniques and systematic random sampling scheme the neuronal density of CA1, CA2 and CA3 of Hippocampus were estimated. Then, the numerical density in each group compared with control group using t-test and ANOVA statistics and Tukey test by Minitab 13 software.Results: Neuronal density average of CA1 area in control, experimental 1 and 2 groups were 37396±553, 10081±233 in CA1 and 10986±382, CA2 area 33045±449, 14648±284 and 17147±378 and in CA3 area 26324±437, 10469±215 and 13829±359 respectively. Statistical analyses showed significant decrease (P<0.001) in the CA1, CA2 and CA3 of Hippocampus neuronal density in experimental groups compared to control group.Conclusion: Aquatic extract of CANNABIS SATIVA leaves has canabinoids substances that may effectively increase dopamine release and inhibit the production of impulse and induce neuronal degeneration in Hippocampus leading to reduction of the neuronal density of Hippocampus.

Cites

References

No record.

Cite

APA: Copy

TEHRANIPOUR, M., KEHTARPOUR, M., JAVAD MOOSAVI, B.Z., & MAHDAVI SHAHRI, N.. (2012). EVALUATION OF CANNABIS SATIVA LEAVES AQUATIC EXTRACT EFFECT ON TRIPLE REGIONS OF HIPPOCAMPUS NEURONAL DENSITY IN MALE RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 14(1), 20-27. SID. https://sid.ir/paper/58366/en

Vancouver: Copy

TEHRANIPOUR M., KEHTARPOUR M., JAVAD MOOSAVI B.Z., MAHDAVI SHAHRI N.. EVALUATION OF CANNABIS SATIVA LEAVES AQUATIC EXTRACT EFFECT ON TRIPLE REGIONS OF HIPPOCAMPUS NEURONAL DENSITY IN MALE RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;14(1):20-27. Available from: https://sid.ir/paper/58366/en

IEEE: Copy

M. TEHRANIPOUR, M. KEHTARPOUR, B.Z. JAVAD MOOSAVI, and N. MAHDAVI SHAHRI, “EVALUATION OF CANNABIS SATIVA LEAVES AQUATIC EXTRACT EFFECT ON TRIPLE REGIONS OF HIPPOCAMPUS NEURONAL DENSITY IN MALE RATS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 1, pp. 20–27, 2012, [Online]. Available: https://sid.ir/paper/58366/en

Related Journal Papers