Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province

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SARMADI A.; Tabatabiefar m.a.; TABATABAEI F.; GHOLIZADEH A.; HASHEMZADE CHALESHTORI M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2018 | Volume:20 | Issue:2 Page(s): 109-118

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Title

Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province

Author(s)

Keywords

MODYQ1

Anti-GAD65Q1

Anti Insulin (II)Q1

C-peptideQ1

Abstract

Background and aims: Diabetes mellitus is a group of metabolic disorders in the body, accompanied with increasing blood sugar levels. Diabetes is classified into 3 groups: Type 1 (T1DM), Type 2 (T2DM) and monogenic diabetes. Maturity-onset diabetes of the young (MODY) is a monogenic diabetes that is frequently mistaken for T1D or T2D. The aim of this study was to diagnose MODY using non-genetic biomarkers and determine its frequency in the population of Isfahan province. This, in addition to saving time and cost, is important for prognosis and appropriate treatment. Methods: In this analytical descriptive study 2085 diabetic patients with a 2-6 years of disease were examined and after assessing the clinical symptoms, in 57 cases with clinical symptoms for MODY, three markers (C-peptide, Anti-GAD65 and anti-insulin (II)) were measured by ELISA method and compared with healthy cases and confirmed T1D and T2D patients. Results: In this analytical descriptive study, among 2085 diabetic patients, in 500 cases of them, the incidence of the disease was before the age of 25 years of old and after measuring 3 mentioned biochemical markers, 41 cases were negative for Anti-GAD65 and anti-Insulin and had detectable C-peptide level and the differences in the levels of these three markers in suspected MODY group were meaningful (P<0. 001 for Anti-GAD65, P<0. 017 for anti-Insulin (II) and P<0. 009 for C-peptide). Conclusion: The use of proprietary non-genetic biomarkers is very valuable for MODY detection and could be used alongside other clinical features to screen a large number of patients with diabetes. Ultimately, only suspect cases must be selected for genetic tests.

Cites

Genetic linkage analysis of GCK and HNF1A genes in a group of families with MODY in Isfahan province of Iran

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APA: Copy

SARMADI, A., Tabatabiefar, m.a., TABATABAEI, F., GHOLIZADEH, A., & HASHEMZADE CHALESHTORI, M.. (2018). Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 20(2 ), 109-118. SID. https://sid.ir/paper/58433/en

Vancouver: Copy

SARMADI A., Tabatabiefar m.a., TABATABAEI F., GHOLIZADEH A., HASHEMZADE CHALESHTORI M.. Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(2 ):109-118. Available from: https://sid.ir/paper/58433/en

IEEE: Copy

A. SARMADI, m.a. Tabatabiefar, F. TABATABAEI, A. GHOLIZADEH, and M. HASHEMZADE CHALESHTORI, “Use of non-genetic biomarkers including anti-GAD65, anti-Insulin (II) and C-peptide in differentiating MODY type diabetes in a population of diabetic patients in Isfahan province,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 2 , pp. 109–118, 2018, [Online]. Available: https://sid.ir/paper/58433/en

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