Comparison of post-acrosomal sheath WWdomain-binding protein and chromatin status of sperm between normozospermic and ab-normozoospermic men

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TAVALAEE M.; AZADI L.; NASR ESFAHANI M.H.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2018 | Volume:20 | Issue:2 Page(s): 1-12

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Title

Comparison of post-acrosomal sheath WWdomain-binding protein and chromatin status of sperm between normozospermic and ab-normozoospermic men

Author(s)

TAVALAEE M. | AZADI L. | NASR ESFAHANI M.H. | Issue Writer Certificate

Keywords

PAWPQ1

DNA damageQ1

Protamine deficiencyQ2

Sperm parametersQ2

Male infertilityQ2

Abstract

Background and aims: Sperm post-acrosomal sheath WWdomain-binding protein (PAWP) was expressed during spermiogenesis and recently introduced as one of sperm factors involved in oocyte activation. So, the aim of this study was to compare sperm PAWP and chromatin status between men with normal (normozoospermia) and abnormal (ab-normozoospermia) Sperm parameters. Methods: Semen samples were assessed according to World Health Organization (2010) protocol and individuals were divided into normozospermia (N=31) and ab-normozoospermia (N=23). Sperm PAWP were assessed by flow cytometry. Sperm DNA damage (TUNEL assay) and Protamine deficiency (chromomycin A3 staining) were assessed by fluorescent microscope in these individuals. Data were analyzed using independent t-test and Pearson coefficient test and by SPSS software. Results: In this study, significant differences were observed in Sperm parameters (concentration, motility, morphology) between men with normozoospermia and ab-normozoospermia (P<0. 001). Mean percentage of sperm PAWP was significantly lower in ab-normozoospermic men compared to normozoospermic men (P<0. 001). In addition, mean percentage of spermatozoa with DNA damage and Protamine deficiency were significantly higher in ab-normozoospermic men compared to normozoospermic men (P<0. 05). Furthermore, significant associations were observed between percentage of sperm PAWP with Sperm parameters (P<0. 05). Conclusion: The results of the current study show that in men with ab-normozoospermia, sperm functional tests such as DNA damage, Protamine deficiency, and also percentage of sperm factor (PAWP) related to oocyte activation were in range of abnormality. Therefore, assessment of these tests can be efficient in the decision of treatment in infertile men.

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APA: Copy

TAVALAEE, M., AZADI, L., & NASR ESFAHANI, M.H.. (2018). Comparison of post-acrosomal sheath WWdomain-binding protein and chromatin status of sperm between normozospermic and ab-normozoospermic men. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 20(2 ), 1-12. SID. https://sid.ir/paper/58435/en

Vancouver: Copy

TAVALAEE M., AZADI L., NASR ESFAHANI M.H.. Comparison of post-acrosomal sheath WWdomain-binding protein and chromatin status of sperm between normozospermic and ab-normozoospermic men. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(2 ):1-12. Available from: https://sid.ir/paper/58435/en

IEEE: Copy

M. TAVALAEE, L. AZADI, and M.H. NASR ESFAHANI, “Comparison of post-acrosomal sheath WWdomain-binding protein and chromatin status of sperm between normozospermic and ab-normozoospermic men,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 2 , pp. 1–12, 2018, [Online]. Available: https://sid.ir/paper/58435/en

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