EFFECT OF ROYAL JELLY ON FIBROSARCOMA TUMOR IN BALB/C MICE

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ZAMANZAD B.; SHIRZADEH H.A.; SHAHINFARD N.; SHIRINZADEH M.; KORD YAZDI RAHIMEH

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Journal: Journal of Shahrekord University of Medical Sciences Year:2009 | Volume:10 | Issue:4 (SUPPL 1 COMPLIMENTARY MEDICINE) Page(s): 64-69

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Title

EFFECT OF ROYAL JELLY ON FIBROSARCOMA TUMOR IN BALB/C MICE

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Keywords

BALB/C MICEQ3

FIBROSARCOMAQ2

ROYAL JELLYQ2

Abstract

Background and aim: FIBROSARCOMA is a tumor with the mesenchymal cell origin that is composed of malignant fibroblastic cell in a collagen background. Specific treatments for cancer such as chemotherapy, radiation and surgery have many complications for patients. ROYAL JELLY is a substance that appears to be effective on immune system. According to the properties of ROYAL JELLY, it seems to be effective on both prevention and growth of FIBROSARCOMA cell. In this study, we aimed to carry out a research to investigate the effect of ROYAL JELLY on the growth of WEHI-164 FIBROSARCOMA cell in singenic BALB/C MICE. Methods: Four groups of 7 BALB/C MICE from same sex and age were selected. All Four groups were subcutaneously injected with WEHI-164 tumor cell on the day zero in the chest area of the animal. Each test group (group 1-3) was orally given 300, 200 and 100 mg/kg of ROYAL JELLY respectively, but control group was not received ROYAL JELLY. In every individual mouse, the tumour size was measured every 2 days from day 5 (days 5, 7, 9, 11, 13, 15 and 17). Data were statistically analyzed using Kruskal-Wallis and Mann Whitney-U tests. Result: Our results showed that the mean size of tumor in case group was significantly smaller than the control group in days 11, 13, 15 and 17 (P<0.05). No metastasis was seen in test and control groups. Conclusion: With emphasize on anti tumor effect of ROYAL JELLY, it seems that ROYAL JELLY has important role in control and regression of FIBROSARCOMA cells. Since ROYAL JELLY showed a delayed effect in control of FIBROSARCOMA, we suggest that ROYAL JELLY be used at least 10 days before tumor inoculation.

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APA: Copy

ZAMANZAD, B., SHIRZADEH, H.A., SHAHINFARD, N., SHIRINZADEH, M., & KORD YAZDI, RAHIMEH. (2009). EFFECT OF ROYAL JELLY ON FIBROSARCOMA TUMOR IN BALB/C MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 10(4 (SUPPL 1 COMPLIMENTARY MEDICINE)), 64-69. SID. https://sid.ir/paper/58516/en

Vancouver: Copy

ZAMANZAD B., SHIRZADEH H.A., SHAHINFARD N., SHIRINZADEH M., KORD YAZDI RAHIMEH. EFFECT OF ROYAL JELLY ON FIBROSARCOMA TUMOR IN BALB/C MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;10(4 (SUPPL 1 COMPLIMENTARY MEDICINE)):64-69. Available from: https://sid.ir/paper/58516/en

IEEE: Copy

B. ZAMANZAD, H.A. SHIRZADEH, N. SHAHINFARD, M. SHIRINZADEH, and RAHIMEH KORD YAZDI, “EFFECT OF ROYAL JELLY ON FIBROSARCOMA TUMOR IN BALB/C MICE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 4 (SUPPL 1 COMPLIMENTARY MEDICINE), pp. 64–69, 2009, [Online]. Available: https://sid.ir/paper/58516/en

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